鹅膏毒肽检测方法的研究进展  

Research Progress in Detection Methods for Amatoxin

作　　者：刘润卿 孙洁芳 牛宇敏[2] 单文宠 邵兵[1,2] LIU Run-qing;SUN Jie-fang;NIU Yu-min;SHAN Wen-chong;SHAO Bing(School of Public Health,Capital Medical University,Beijing 100069,China;Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning,Beijing Center for Disease Prevention and Control,Beijing 100013,China;Beijing Advanced Innovation Center for Food Nutrition and Human Health,College of Veterinary Medicine,China Agricultural University,Beijing 100193,China)

机构地区：[1]首都医科大学公共卫生学院,北京100069 [2]北京市疾病预防控制中心食物中毒诊断溯源技术北京市重点实验室,北京100013 [3]中国农业大学动物医学院北京食品营养与人类健康高精尖创新中心,北京100193

出　　处：《分析测试学报》2021年第4期503-509,共7页Journal of Instrumental Analysis

基　　金：首都卫生发展科研专项(2018-4-1014);国家重点研发计划食品安全关键技术研发重点专项(2018YFC1602600);北京市城市管理能力提升专项重大项目(D171100008317001)。

摘　　要：一直以来毒蘑菇中毒在全球范围内频发,成为最常见的食物中毒事件之一,也是食物中毒致死的最主要原因。毒蘑菇中含量最高、致死性最强的毒素为鹅膏毒肽。因此,鹅膏毒素准确快捷的检测对鉴别中毒源、患者后续治疗及预防有着重要意义。目前,鹅膏毒肽的常用检测方法包括色谱-质谱联用技术以及一些基于免疫识别和特殊化学结构的检测技术。而不断开发特异性强、灵敏度高、检测时间短的新型检测方法仍是目前的研究热点和重点。该文就鹅膏毒肽的检测方法进行综述,以期引起研究同行对此领域的关注,以激发更多的研究思路。Mushroom poisoning occurs frequently all over the world,which has become one of the most common food poisoning events,as well as the main cause of death from food poisoning.Meanwhile,the most and deadliest toxin in the poisonous mushroom is amatoxin.Hence,rapid and accurate detection of amanitin is of great significance for the identification of toxic source,and the subsequent treatment and prevention of patients.At present,the common methods for amanitin detection include chromatography-mass spectrometry and some other detection techniques based on immune recognition and special chemical structures.It is still the focus of current research that the development of new detection methods with strong specificity,high sensitivity and low time-consumption.Therefore,the detection methods of amanitin are reviewed in this paper in order to arouse the attention of research colleagues in this field and stimulate more research ideas.

关 键 词：蘑菇中毒 鹅膏毒肽 质谱 快速检测 研究进展 

分 类 号：O629.72[理学—有机化学] G353.1[理学—化学]