急性期精神病治疗中奥氮平的应用效果与安全性初步研究  

Preliminary study on the effect and safety of olanzapine in the treatment of acute psychosis

作　　者：赵朝庆 闫冬惠 ZHAO Chaoqing;YAN Dong-hui(Department of Psychiatry,Liaocheng Fourth People’s Hospital,Liaocheng 252000,China)

机构地区：[1]聊城市第四人民医院精神科,252000

出　　处：《中国现代药物应用》2021年第8期123-125,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析奥氮平治疗急性期精神病的疗效和安全性。方法选取66例急性期精神病患者作为研究对象,采取随机双盲法分为观察组与对照组,每组33例。对照组患者口服氯氮平治疗,观察组患者口服奥氮平治疗。对比两组患者治疗效果,治疗前后简明精神病评定量表(BPRS)评分,治疗前后心理状态[抑郁自评量表(SDS)、焦虑自评量表(SAS)]评分,不良反应发生情况。结果观察组患者治疗总有效率为93.9%,明显高于对照组的75.8%,差异具有统计学意义(P<0.05)。两组患者治疗前的BPRS评分比较,差异无统计学意义(P>0.05);治疗1 d、2 d、3 d、1周后的BPRS评分均显著低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患者SAS、SDS评分比较,差异无统计学意义(P>0.05);治疗后,观察组患者SAS评分(43.5±5.5)分、SDS评分(41.6±5.2)分均明显低于对照组的(64.2±6.0)、(60.6±5.4)分,差异具有统计学意义(P<0.05)。观察组患者的口干、乏力、嗜睡、头昏、食欲增加发生率均低于对照组,差异具有统计学意义(P<0.05)。结论急性期精神病患者应用奥氮平治疗可取得很好的疗效,且治疗安全性较高,此治疗方案相比于氯氮平治疗更值得推广应用。Objective To analyze the efficacy and safety of olanzapine in the treatment of acute psychosis.Methods A total of 66 patients with acute psychosis as study subjects were divided into observation group and control group according to random double-blind method,with 33 cases in each group.The control group was treated with oral olanzapine,and the observation group was treated with oral cozapine.The therapeutic effect,brief psychiatric rating scale(BPRS)score and mental state[self-rating depression scale(SDS)and selfrating anxiety scale(SAS)]score before and after treatment,and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 93.9%,which was obviously higher than 75.8%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in BPRS score between the two groups(P>0.05).After 1 d,2 d,3 d and 1 week of treatment,the BPRS scores of the observation group were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in SAS score and SDS score between the two groups(P>0.05).After treatment,the SAS score(43.5±5.5)points and SDS score(41.6±5.2)points of the observation group were obviously lower than(64.2±6.0)and(60.6±5.4)points of the control group,and the difference was statistically significant(P<0.05).The incidence of dry mouth,fatigue,lethargy,dizziness,increased appetite of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with cozapine,olanzapine shows good efficacy and high safety on patients with acute psychosis.It is worthy of promotion and application.

关 键 词：急性期精神病 奥氮平 氯氮平 疗效 安全性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]