环保形势下抗生素发酵无菌管理  

Aseptic Management of Antibiotic Fermentation

作　　者：郭雷 邹智永 牛玉芳 侯新龙 俞天南 GUO Lei;ZOU Zhiyong;NIU Yufang;HOU Xinlong;YU Tiannan(Shandong Lukang Shelile Pharmaceutical Co.,Ltd.,Shandong Jining 272000)

机构地区：[1]山东鲁抗舍里乐药业有限公司,山东济宁272000

出　　处：《生物化工》2021年第2期130-132,共3页Biological Chemical Engineering

摘　　要：在抗生素原料药发酵生产过程中,无菌控制直接关系到抗生素生产水平及产品质量。抗生素原料药生产过程涉及大量生物化学反应,产生的废水、废气、废菌渣量大且成分复杂,处理存在一定难度,是环保核查的重点对象。本文主要探讨了在目前的环保形势下,抗生素发酵生产实践中关于无菌管理的预防控制措施。In the fermentation process of antibiotic raw materials,sterility control is directly related to antibiotic production level and product quality.The production process of antibiotic API involves a large number of biochemical reactions,resulting in a large amount of wastewater,waste gas,waste bacterial residue and complex composition,which is difficult to be treated,and it is the key object of environmental protection verification.This paper mainly discusses the prevention and control measures of aseptic management in antibiotic fermentation production practice under the current environmental protection situation.

关 键 词：环保 抗生素发酵 无菌管理 

分 类 号：TQ927[轻工技术与工程—发酵工程]