Expression of COX-2 and transcription factor CCAAT enhancer binding proteinβin refractory sinusitis with nasal polyps and its significance  

作　　者：Jingyu Gao Fanxing Meng Chaowu Jiang Yongmei Yu Ruan Biao 

机构地区：[1]Department of Otolaryngology Head and Neck Surgery,The First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,650032,China [2]Department of Otolaryngology Head and Neck Surgery,Baoding First Central Hospital of Hebei Province Baoding,Hebei,071000,China

出　　处：《中国医学文摘（耳鼻咽喉科学）》2021年第2期11-17,共7页Chinese Medical Digest(Otorhinolaryngology)

基　　金：Health Science and Technology Program of Yunnan Province(No.2010NS034);Joint Special Project of Yunnan Provincial Science and Technology Department/Kunming Medical University Applied Basic Research(No.201901C07041)。

摘　　要：Objective To study the expression and significance of COX-2 and C/EBP-βin refractory sinusitis with nasal polyps,and to explore the relationship between them and the recurrence of sinusitis with nasal polyps.Methods The protein expression of COX-2 and C/EBP-βin 20 cases of refractory sinusitis with nasal polyps,20 cases of sinusitis with nasal polyps and 20 cases of normal nasal mucosa were detected by western blot,and the relationship between the two was compared.Results The expression levels of COX-2 and C/EBP-βin refractory sinusitis with nasal polyps were significantly different from those in refractory sinusitis with nasal polyps(P<0.05);The expression levels of COX-2 and C/EBP-βin sinusitis tissues with nasal polyps were significantly different from those in normal nasal mucosa tissues(P<0.05);The expression levels of COX-2 and C/EBP-βin each group were significantly correlated(P<0.05).Conclusions The high expression of COX-2 and C/EBP-βmay be closely related to postoperative recurrence of sinusitis patients with nasal polyps.Both may be used as objective indicators to judge the postoperative follow-up and recurrence tendency of patients with sinusitis with nasal polyps..

关 键 词：Cyclooxygenase-2 Transcription factor CCAAT enhancer binding proteinβ Refractory sinusitis with nasal polyps IMMUNOBLOT 

分 类 号：R73[医药卫生—肿瘤]