膀胱癌分子机制及分子分型的研究进展  

Advances in molecular mechanism and molecular subtype of bladder cancer

作　　者：孔家瑾 张璐[2] 郑克文[1] KONG Jiajin;ZHANG Lu;ZHENG Kewen(Department of Urology,First Affiliated Hospital of Wenzhou Medical University,First Clinical College of Wenzhou Medical University,Wenzhou,Zhejiang,325000,China;Institute of Cancer and Basic Medicine,Chinese Academy of Sciences,Department of GCP,Cancer Hospital of the University of Chinese Academy of Sciences,Department of GCP,Zhejiang Cancer Hospital)

机构地区：[1]温州医科大学附属第一医院泌尿外科,温州医科大学第一临床学院,浙江温州325000 [2]中国科学院肿瘤与基础医学研究所,中国科学院大学附属肿瘤医院GCP中心,浙江省肿瘤医院GCP中心

出　　处：《临床泌尿外科杂志》2021年第3期236-241,共6页Journal of Clinical Urology

基　　金：浙江省自然科学基金(No:LQ17H050002,LQ17H300002)。

摘　　要：膀胱癌是世界上最常见的癌症之一。研究表明膀胱癌是一组具有不同临床病程和不同治疗反应的分子异质性疾病,其发生发展与多条分子通路相关。利用分子生物学技术对膀胱癌进行分子分型有望提高疾病的诊治水平。本文综述了近年来膀胱癌分子病理学和膀胱癌分子亚型分类的研究进展。Bladder cancer is one of the most common cancers in the world. Studies have shown that bladder cancer is a group of molecular heterogeneous diseases with different clinical courses and treatment responses, and its occurrence and development are related to multiple molecular pathways. Molecular classification of bladder cancer by molecular biology is expected to improve the diagnosis and treatment of the disease. This paper reviews the recent advances in molecular pathology and subtype classification of bladder cancer.

关 键 词：膀胱癌 分子分型 分子通路 突变谱 

分 类 号：R737.14[医药卫生—肿瘤]