非小细胞肺癌组织MAGE-A3、HIF-1α、MTA1表达与临床病理参数及复发转移的关系研究  

Study on the Relationship between the Expression of MAGE-A3,HIF-1α,MTA1,Clinicopathological Parameters,Recurrence and Metastasis in Non Small Cell Lung Cancer

作　　者：邓万生 孙振 王伟 郑福爽[2] 曹辉 DENG Wan-sheng;SUN Zhen;WANG Wei;ZHENG Fu-shuang;CAO Hui(Department of Thoracic Surgery,Angang Group General Hospital,Anshan,Liaoning,114000,China;Department of Thoracic Surgery,Shengjing Hospital Affiliated to China Medical University,Anshan,Liaoning,114000,China;Department of Pathology,Angang Group General Hospital,Anshan,Liaoning,114000,China)

机构地区：[1]鞍钢集团公司总医院胸外科,辽宁鞍山114000 [2]中国医科大学附属盛京医院胸外科,辽宁沈阳110004 [3]鞍钢集团公司总医院病理科,辽宁沈阳110004

出　　处：《现代生物医学进展》2021年第5期945-949,共5页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(30979171);辽宁省自然科学基金计划项目(20180530020)。

摘　　要：目的:探讨非小细胞肺癌组织黑色素瘤相关抗原-A3(MAGE-A3)、缺氧诱导因子-1α(HIF-1α)、转移相关蛋白1(MTA1)表达与临床病理参数及复发转移的关系。方法:选择2015年2月至2018年1月我院诊治的130例非小细胞肺癌患者进行临床研究,采用免疫组织化学染色法检测其非小细胞癌组织及癌旁组织中MAGE-A3、HIF-1α、MTA1的表达,分析MAGE-A3、HIF-1α、MTA1的表达与各项临床病理参数的关系。对比不同MAGE-A3、HIF-1α、MTA1表达情况患者的转移率及复发率。结果:130例非小细胞肺癌组织中MAGE-A3、HIF-1α、MTA1阳性率分别为70.77%、74.62%、79.23%,明显高于癌旁组织的25.38%、22.31%、17.69%(P<0.05)。非小细胞肺癌组织中MAGE-A3、HIF-1α、MTA1表达与淋巴结转移和TNM分期相关(P<0.05)。MAGE-A3、HIF-1α、MTA1阳性患者转移/复发率明显高于MAGE-A3、HIF-1α、MTA1阴性患者(P<0.05)。结论:MAGE-A3、HIF-1α、MTA1在非小细胞肺癌中阳性表达率升高,并且均与非小细胞肺癌淋巴结转移、TNM分期和转移复发相关,在非小细胞肺癌的诊断和预后评估中具有一定临床意义。Objective:To investigate the relationship between the expression of melanoma associated antigen-A3(MAGE-A3),hypoxia inducible factor-1α(HIF-1α),metastasis associated protein-1(MTA1)and clinicopathological parameters,recurrence and metastasis of non small cell lung cancer(NSCLC).Methods:130 cases of NSCLC who were diagnosed and treated in our hospital from february 2015 to January 2018 were selected for clinical study.The expression of MAGE-A3,HIF-1αand MTA1 in NSCLC and its adjacent tissues were detected by immunohistochemistry.The relationship between the expression of MAGE-A3,HIF-1αand MTA1 and various clinicopathological parameters was analyzed.The metastasis rate and recurrence rate of patients with different expression of MAGE-A3,HIF-1αand MTA1 were compared.Results:The positive rates of MAGE-A3,HIF-1αand MTA1 in 130 NSCLC tissues were 70.77%,74.62%and 79.23%,respectively,which were significantly higher than those in adjacent tissues(25.38%,22.31%,17.69%)(P<0.05).The expression of MAGE-A3,HIF-1αand MTA1 in NSCLC was correlated with lymph node metastasis and TNM stage(P<0.05).The metastasis rate and recurrence rate of MAGE-A3,HIF-1α,MTA1 positive patients were significantly higher than those of MAGE-A3,HIF-1α,MTA1 negative patients(P<0.05).Conclusion:The positive expression rate of MAGE-A3,HIF-1αand MTA1 in NSCLC is increased,and they are all related to lymph node metastasis,TNM stage and metastasis recurrence of NSCLC.

关 键 词：非小细胞肺癌 黑色素瘤相关抗原-A3 缺氧诱导因子-1Α 转移相关蛋白1 临床病理参数 复发 转移 

分 类 号：R734.2[医药卫生—肿瘤]