瞬时弹性成像技术对非酒精性单纯性脂肪肝的诊断价值及受控衰减系数与糖脂代谢的相关性分析  

The Diagnostic Value of Transient Elastography in Nonalcoholic Simple Fatty Liver and the Correlation between Controlled Attenuation Coefficient and Glycolipid Metabolism

作　　者：王雨[1] 王楠[2] 韩璐 曲长君 刘媛媛 付建军[2] WANG Yu;WANG Nan;HAN Lu;QU Chang-jun;LIU Yuan-yuan;FU Jian-jun(Department of Gastroenterology,Xi’an Central Hospital,Xi'an,Shanxi,710004,China;Department of Infectious Disease,Xi’an Central Hospital,Xi'an,Shanxi,710004,China;Department of Ultrasound Diagnosis,Xi’an Central Hospital,Xi'an,Shanxi,710004,China;Department of Imaging,Xi’an Central Hospital,Xi'an,Shanxi,710004,China)

机构地区：[1]西安市中心医院消化科,陕西西安710004 [2]西安市中心医院感染科,陕西西安710004 [3]西安市中心医院超声诊断科,陕西西安710004 [4]西安市中心医院影像科,陕西西安710004

出　　处：《现代生物医学进展》2021年第5期958-961,986,共5页Progress in Modern Biomedicine

基　　金：陕西省社会发展科技攻关项目(2016SF-624);西安市科技计划项目[2019115413YX009SF042(4)]。

摘　　要：目的:探讨瞬时弹性成像技术(FibroTouch)对非酒精性单纯性脂肪肝(NAFLD)的诊断价值及受控衰减系数(CAPTM)与糖脂代谢的相关性分析。方法:选取2017年8月~2019年8月期间本院收治的NAFLD患者117例为研究对象,纳入实验组,另选同期在我院进行健康体检的健康受试者80例为对照组。对实验组患者和对照组受试者进行FibroTouch检查、腹部彩色多普勒超声检查、糖脂代谢指标生化检查。对比两组受试者的糖脂代谢指标水平、CAPTM水平、FibroTouch检查与彩色多普勒超声检查诊断NAFLD的准确率,分析CAPTM水平与糖脂代谢指标水平的相关性。结果:实验组空腹血糖(FPG)、糖化血红蛋白(HbA1C)、空腹胰岛素(FINS)水平均高于对照组(P<0.05)。实验组甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、载脂蛋白A(apoA)、CAPTM水平均高于对照组(P<0.05)。FibroTouch检查NAFLD的准确率高于彩色多普勒超声检查(P<0.05)。经Pearson相关性分析显示,CAPTM与各项糖脂代谢指标均呈正相关性(P<0.05)。结论:相比于彩色多普勒超声检查,FibroTouch用于NAFLD的诊断准确率更高,FibroTouch检查参数CAPTM与糖脂代谢指标存在明显的相关性,可辅助用于NAFLD的诊断和病情评估。Objective:To study the diagnostic value of FibroTouch(FibroTouch)in nonalcoholic simple fatty liver(NAFLD)and the correlation between controlled attenuation coefficient(captm)and glycolipid metabolism.Methods:117 patients with NAFLD who were admitted to our hospital from August 2017 to August 2019 were selected as the study subjects and 80 healthy subjects who had physical examination in our hospital at the same time were selected as the control group.The patients in the experimental group and the control group were examined by FibroTouch,abdominal color Doppler ultrasound and biochemical examination of glycolipid metabolism.The level of glycolipid metabolism index,captm,the accuracy rate of fiberscan and color Doppler ultrasound in diagnosing NAFLD,and the correlation between captmand glycolipid metabolism index were analyzed.Results:The levels of Fasting blood glucose(FPG),Glycosylated hemoglobin(HbA1 c),and Fasting insulin(fins)in the experimental group were higher than those in the control group(P<0.05).Triglyceride(TG),total cholesterol(TC),low density lipoprotein(LDL-C),apolipoprotein A(ApoA)and captmin the experimental group were higher than those in the control group(P<0.05).The accuracy of NAFLD in fibrotouch was higher than that in CDUS(P<0.05).By Pearson correlation analysis,captmwas positively correlated with each index of glycolipid metabolism(P<0.05).Conclusion:Transient elastography can be used in the diagnosis of nonalcoholic simple fatty liver with higher accuracy than ultrasound.There is a significant correlation between captmand glycolipid metabolism index,it can be used for diagnosis and evaluation of NAFLD.

关 键 词：非酒精性单纯性脂肪肝 瞬时弹性成像技术 彩色多普勒超声 受控衰减系数 糖脂代谢 

分 类 号：R575.5[医药卫生—消化系统] R445.1[医药卫生—内科学]