四逆散加味治疗非糜烂性胃食管反流病(肝胃气滞型)的疗效评价  

Efficacy evaluation of Modified Sini Powder on non-erosive gastroesophageal reflux disease(stagnation of liver and stomach qi)

作　　者：程伟慧 许英铭 黄晓静 CHENG Weihui;XU Yingming;HUANG Xiaojing(DepartmentⅡof Internal Medicine,Yangjiang Hospital of Traditional Chinese Medicine,Guangdong,Yangjiang 529500,China)

机构地区：[1]广东省阳江市中医医院内二科,广东阳江529500

出　　处：《中国医药科学》2021年第5期78-80,105,共4页China Medicine And Pharmacy

基　　金：广东省阳江市医疗卫生类科技计划项目(阳科通[2019]50-62)。

摘　　要：目的探究四逆散加味治疗非糜烂性胃食管反流病(肝胃气滞型)的临床效果。方法选择广东省阳江市中医医院2018年8月至2020年7月收治的非糜烂性胃食管反流病(肝胃气滞型)患者100例为研究对象,采用随机数字表法分为对照组50例与观察组50例,对照组给予常规西药治疗,观察组采用四逆散加味治疗,比较两组中医证候疗效、治疗前后反流性疾病问卷(RDQ)评分及不良反应发生情况。结果观察组中医证候总有效率96.00%高于对照组的82.00%,差异有统计学意义(P<0.05);治疗前两组RDQ评分中烧心、胸骨后痛、反酸、反食评分比较,差异无统计学意义(P>0.05),治疗后观察组烧心、胸骨后痛、反酸、反食评分低于对照组,差异有统计学意义(P<0.05);两组均未发生严重不良反应。结论四逆散加味治疗非糜烂性胃食管反流病(肝胃气滞型)疗效显著,可有效改善患者烧心、胸骨后痛、反酸、反食等症状,安全性高,值得临床应用与推广。Objective To investigate the clinical efficacy of Modified Sini Powder on non-erosive gastroesophageal reflux disease(stagnation of liver and stomach qi).Methods A total of 100 patients with non-erosive gastroesophageal reflux disease(stagnation of liver and stomach qi)admitted to Yangjiang Hospital of Traditional Chinese Medicine,Guangdong from August 2018 to July 2020 were selected as the research objects,and they were divided into the control group(n=50)and the observation group(n=50)according to the random number table method.The control group was treated with conventional western medicine,while the observation group was treated with Modified Sini Powder.The therapeutic efficacy of traditional Chinese medicine(TCM)syndromes,the score of reflux disease questionnaire(RDQ)and the incidence of adverse reactions(ADRs)were compared between the two groups before and after treatment.Results The total efficacy rate of TCM syndromes in the observation group was 96.00%,higher than 82.00%in the control group,with statistically significant difference(P<0.05).Before treatment,there were no statistically significant differences in the RDQ scores of heartburn,retrosternal pain,acid regurgitation and regurgitation between the two groups(P>0.05).However,after treatment,the scores of heartburn,retrosternal pain,acid regurgitation and regurgitation in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).There were no serious ADRs occurred in both groups.Conclusion The Modified Sini Powder has significant therapeutic efficacy on non-erosive gastroesophageal reflux disease(stagnation of liver and stomach qi),and it can effectively improve the symptoms of heartburn,retrosternal pain,acid regurgitation and regurgitation.Therefore,it is safe and worthy of clinical application and promotion.

关 键 词：四逆散 非糜烂性胃食管反流病 肝胃气滞 中医 反流性疾病问卷 

分 类 号：R571[医药卫生—消化系统]