蛋白质O-GlcNAc修饰对缺血再灌注损伤保护机制的研究进展  

Research Progress of Protective Mechanism of Protein’s O-GlcNAcylation on Ischemia-Reperfusion Injury

作　　者：吴科帆 江梦[1] 夏中元[1] WU Kefan;JIANG Meng;XIA Zhongyuan(Department of Anesthesiology,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院麻醉科,武汉430060

出　　处：《医学综述》2021年第8期1464-1468,1474,共6页Medical Recapitulate

基　　金：国家自然科学基金(81671891,81801309)。

摘　　要：蛋白质的修饰是研究蛋白质功能的重要内容和方向,氧连-N-乙酰葡糖胺(O-GlcNAc)修饰作为一种细胞内普遍存在的重要蛋白质修饰方式,可以改变蛋白质的功能、半衰期及其具体活性细胞的位置。近年来,随着O-GlcNAc修饰所调控的关键途径的发现,O-GlcNAc修饰在缺血再灌注损伤中的作用机制被进一步阐明,如何精准高效调控关键途径中蛋白的O-GlcNAc修饰水平成为当前研究的热点,对关键蛋白O-GlcNAc修饰水平的精准调控可以降低组织的缺血再灌注损伤,为临床缺血再灌注损伤的治疗提供了新的思路。Protein modification is an important content and direction in the study of protein function.O-GlcNAcylation,as an important protein modification method,can change protein function,protein half-life and the specific cellular location of protein activity.In recent years,with the discovery of the key pathway regulated by O-GlcNAcylation,the mechanism of O-GlcNAcylation on ischemia-reperfusion injury has been further elucidated.How to accurately and efficiently regulate the level of O-GlcNAcylation of key proteins has become a hot spot of the current research.Precise adjustment of the level of O-GlcNAcylation of key proteins can reduce the ischemia-reperfusion injury of tissues,which provides a new way for the treatment of ischemia-reperfusion injury in clinical.

关 键 词：缺血再灌注损伤 氧连-N-乙酰葡糖胺修饰 己糖胺途径 细胞应激 

分 类 号：R363.22[医药卫生—病理学]