新生血管性眼病实验模型的构建与评估  

Construction and evaluation of experimental models of neovascular eye diseases

作　　者：宦晨阳 马立沙 沈炜[1] HUAN Chen-yang;MA Li-sha;SHEN Wei(Department of Ophthalmology,Changhai Hospital,Naval Medical University(Second Military Medical University),Shanghai 200433,China)

机构地区：[1]海军军医大学(第二军医大学)长海医院眼科,上海200433

出　　处：《第二军医大学学报》2021年第4期420-425,共6页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(81700839);中国博士后科学基金(2018M632122);上海市晨光计划(18CG40).

摘　　要：血管生成是一个复杂的过程,在生长发育、组织和器官再生及许多病理改变中起着重要作用。眼部病理性的血管生成是新生血管性眼病的主要特征,会导致患者视力下降甚至失明。因此,新生血管性眼病的实验模型对于研究抗血管生成治疗方法至关重要。本文综述了目前常用的研究新生血管性眼病的实验模型及其量化评估方法,分析了不同实验模型的优点和局限性,有助于研究人员选择合适的实验模型。Angiogenesis is a complex process playing important roles in growth and development,tissue and organ regeneration,and many pathological changes.Pathological angiogenesis in the eye is the main feature of neovascular eye diseases,which can lead to visual loss or even blindness.Therefore,experimental models of neovascular eye diseases are very important for the development of antiangiogenic therapy.This paper reviews the commonly used experimental models of neovascular eye diseases and their quantitative evaluation,and analyzes their advantages and limitations,helping researchers to choose the most appropriate models for their studies.

关 键 词：眼疾病 病理性新生血管化 生物学模型 量化评估 

分 类 号：R77[医药卫生—眼科]