甲基苯丙胺成瘾男性患者脑白质结构网络特征研究  

Aberrant topology of white matter networks in male patients with methamphetamine dependence

作　　者：程萍 李亚迪[1] 董海波 周文华 沈雯雯 张建兵 梁良 王高燕 Cheng Ping;Li Yadi;Dong Haibo;Zhou Wenhua;Shen Wenwen;Zhang Jianbing;Liang Liang;Wang Gaoyan(Department of Radiology,Lihuili Hospital Affiliated to Medical School of Ningbo University(Ningbo Medical Center Lihuili Hospital),Ningbo 315040,China;Laboratory of Behavioral Neuroscience,Ningbo Addiction Research and Treatment Center,Ningbo 315010,China)

机构地区：[1]宁波大学附属李惠利医院(宁波市医疗中心李惠利医院)放射科,315040 [2]宁波成瘾研究与治疗中心行为神经科学实验室,315010

出　　处：《中华精神科杂志》2021年第2期111-118,共8页Chinese Journal of Psychiatry

基　　金：科技部慢病重大专项(2017YFC1310403);国家重点基础研究计划(973计划)(2015CB553504);国家自然科学基金(81471350,81671321);浙江省医药卫生科技计划项目(2018243996);浙江省基础公益研究计划项目(LGF21H090007);宁波市自然科学基金项目(2014A610259,2019A610296);宁波市科技局公益类科技计划项目(202002N3166)。

摘　　要：目的探讨甲基苯丙胺(methamphetamine,MA)成瘾患者脑白质结构网络的拓扑特征。方法2014年2月至2019年10月,基于弥散张量成像数据,利用概率纤维追踪技术构建MA成瘾男性患者(MA组,n=46)及男性健康对照者(对照组,n=46)的脑白质结构网络。应用基于网络的统计方法评估2组脑白质连接的差异,再用一般线性模型对2组的网络参数进行比较,并分析有显著组间差异的网络参数与临床变量之间的相关性。结果MA组和对照组的脑结构网络均具有小世界属性;与对照组相比,MA组显著增加的结构连接主要位于奖赏系统和视觉系统;最短路径长度显著减低,聚类系数、全局效率、局部效率明显增高(t值分别约为:-2.890、3.179、3.918、3.077,P<0.01,置换检验10000次);MA组主要在眶额皮质和顶颞叶皮质区域介数中心度明显减低,而左腹侧前岛叶显著增高(P<0.05,置换检验5000次),此外,右丘脑(r=-0.410,P=0.005)、左额上回(r=-0.331,P=0.026)、左楔前叶(r=-0.410,P=0.005)、右楔前叶(r=-0.337,P=0.024)、左颞中回(r=-0.341,P=0.022)、右缘上回(r=-0.317,P=0.034)的介数中心度与简明精神病评定量表(Brief Psychiatric Rating Scale,BPRS)缺乏活力因子分呈负相关,右胼胝体沟的介数中心度与思维障碍因子分(r=-0.318,P=0.033)、右丘脑的介数中心度与BPRS总分(r=-0.342,P=0.022)及激活性因子分(r=-0.326,P=0.029)呈负相关。结论MA成瘾患者的大脑结构网络仍具有小世界属性,但其大脑区域间的信息传输和整合效率显著提高,且部分脑区的介数中心度能够在一定程度上反映精神病性症状的严重程度。Objective To investigate the topological alterations of white matter networks in methamphetamine(MA)-dependent patients.Methods Diffusion tensor imaging(DTI)-based probabilistic tractography was used to map the white matter networks in 46 male MA-dependent patients(MA group)and 46 male healthy controls(control group).A network-based statistic(NBS)approach was used to evaluate the differences in the white matter connections between the two groups,and then a general linear model was used to compare the topological properties between two groups,and the correlation between the network parameters with significant differences between groups and the clinical variables were analyzed.Results The study found the brain structural network for both MA group and control group presented with characteristics of a small-world network.The significantly increased structural connections in the MA group are mainly located in the reward system and visual system.The shortest path length in MA group was significantly reduced,while the clustering coefficient,global efficiency and local efficiency were significantly increased(t=-2.890,3.179,3.918,3.077,P<0.01 after the 10000 permutation test).The study also found that the betweenness centrality in MA group was significantly reduced in the orbitofrontal cortex and the parietal temporal cortex,while the left ventral anterior insula was significantly increased(P<0.05 after the 5000 permutation test).In addition,the betweenness centrality of the right thalamus,the left superior frontal gyrus,left precuneus,right precuneus,left middle temporal gyrus,and right superior marginal gyrus was negatively correlated to the lack of vitality factor score in the BPRS,and the negative correlations were found between the betweenness centrality of the right corpus callosum sulcus and the thinking disorder factor score,and the betweenness centrality of the right thalamus was also negatively correlated with total BPRS score as well as the activity factor score;the correlation coefficients r and P were r=-0.41

关 键 词：甲基苯丙胺 物质相关性障碍 脑结构网络 图论 弥散张量成像 

分 类 号：R749.61[医药卫生—神经病学与精神病学]