酒依赖患者急性脱瘾治疗后大脑皮质厚度的磁共振成像研究  

Magnetic resonance imaging study of cerebral cortex thicknesses in alcohol dependent patients after acute detoxication

作　　者：杨可冰[1] 杨清艳[1] 赵荣江[1] 牛雅娟[1] 于婷[1] 范丰梅[1] 范洪振 谭云龙[1] Yang Kebing;Yang Qingyan;Zhao Rongjiang;Niu Yajuan;Yu Ting;Fan Fengmei;Fan Hongzhen;Tan Yunlong(Beijing Huilongguan Hospital,Peking University Huilongguan Clinical Medical School,Beijing 100096,China)

机构地区：[1]北京回龙观医院,北京大学回龙观临床医学院,100096

出　　处：《中华精神科杂志》2021年第2期119-124,共6页Chinese Journal of Psychiatry

基　　金：北京市医院管理局临床医学发展专项经费资助(XMLX201834);北京市属医院科研培育项目(PX2017067);北京市卫生与健康科技成果和适宜技术推广项目(2018-TG-22)。

摘　　要：目的探索急性脱瘾治疗后酒依赖患者脑区皮质厚度的异常特征及与酒依赖临床特征的关联。方法以2017年4月至2018年4月的住院男性酒依赖患者(患者组,n=33)与年龄、受教育程度匹配的健康对照(对照组,n=35)为研究对象,收集大脑皮质功能磁共振的影像学数据和患者一般人口学及临床资料;使用FreeSurfer软件处理影像学数据并计算双侧74个脑区的皮质厚度,采用协方差分析的方法比较2组间各脑区皮质厚度的差异,并对差异脑区皮质厚度与患者的临床特征进行相关分析。结果患者组皮质厚度在左侧枕中回、右侧枕上回、双侧顶下角回、双侧顶下缘上回、双侧顶上回、左侧枕极及右侧顶内沟均显著小于对照组(均P<0.00034,经Bonferoni校正);酒依赖患者初始饮酒年龄与左侧顶上回皮质厚度呈正相关(r=0.428,P=0.024)。结论顶叶后部皮质厚度的减少可能是酒依赖患者较为特征性的皮质损伤,初始饮酒年龄可能对左侧顶上回皮质的影响更明显。Objective To explore the abnormal features of cortical thickness of brain regions in patients with alcohol dependence(PADs)after acute detoxication and the correlation with clinical features of PADs.Methods In this study,male inpatients with alcohol dependence(patient group,n=33)and healthy controls(control group,n=35)matched with age and education were enrolled during the period of Apr 2017 to Apr 2018.Brain functional magnetic resonance imaging(MRI)data,general demographic and clinical information were collected.FreeSurfer software was used to process the MRI data and compute the bilateral cortical thickness across 74 brain regions.Analysis of covariance(ANCOVA)was performed to analyse the differences of cortical thickness in different brain regions between the two groups,and the correlation between the cortex thickness and their clinical features in PADs was explored by using correlation analysis.Results Compared with HCs,PADs showed significantly decreased cortical thickness of brain regions in the left middle and pole occipital,right superior occipital gyri,bilateral superior and inferior parietal gyri,and right intraparietal sulcus(all P<0.00034,after Bonferroni correction).Positive correlation was found between the thickness of left superior parietal gyrus(SPG)and initial drinking age(r=0.428,P=0.024)in PADs.Conclusion The cortex thickness reduction of bilateral posterior parietal cortex might be a more characteristic injury in PADs.Furthermore,the initial drinking age may have a more obvious effect on the cortex of the left SPG.

关 键 词：磁共振成像 酒依赖 皮质厚度 

分 类 号：R749.62[医药卫生—神经病学与精神病学]