Clinicopathological features of superficial CD34-positive fibroblastic tumor  

作　　者：Li Ding Wen-Jing Xu Xiao-Ying Tao Liang Zhang Zhao-Gen Cai 

机构地区：[1]Department of Pathology,The First Affiliated Hospital of Bengbu Medical College,Bengbu 233000,Anhui Province,China [2]Department of Pathology,Hangzhou People's Hospital,Hangzhou 310000,Zhejiang Province,China [3]Department of Pathology,Huaiyuan County People's Hospital,Bengbu 233000,Anhui Province,China

出　　处：《World Journal of Clinical Cases》2021年第12期2739-2750,共12页世界临床病例杂志

基　　金：Key Projects of Natural Science Research in Colleges and University of Anhui Province,No.2017A236.

摘　　要：BACKGROUND Superficial CD34-positive fibroblastoma(SCPFT)is a newly discovered mesenchymal tumor characterized by high polymorphism,low mitotic rate,and diffuse CD34-positive reactions.AIM To further determine the clinicopathological features of SCPFT.METHODS We retrospectively analyzed the clinicopathological data,immunohistochemistry results,and differential diagnoses of four patients with SCPFT and performed a literature review.Relevant fusion genes were also detected.RESULTS The tumors were all located in the lower extremities and presented as slowgrowing painless masses located in the dermis and subcutaneous tissue.Microscopically,the tumors were composed of spindle-shaped to epithelioid cells with scattered abnormal and pleomorphic nuclei on a fibrous or fibromyxoid background.Necrosis was not found in the tumor tissues,and mitotic figures were rare.Immunohistochemically,the tumor cells were strongly positive for vimentin and CD34,and CKpan showed focal positivity in two tumors.All four patients were followed(13-57 mo,mean 35 mo),and one patient experienced local recurrence.CONCLUSION SCPFT is a newly discovered borderline mesenchymal tumor that can locally recur or even metastasize.Familiarity with its clinicopathological features will help avoid confusion with skin mesenchymal tumors with similar features.

关 键 词：SUPERFICIAL Fibroblastoma CD34 IMMUNOHISTOCHEMISTRY Fluorescence in situ hybridization CLINICOPATHOLOGY 

分 类 号：R730.43[医药卫生—肿瘤]