《伤寒杂病论》中含人参的方剂分析  

Analysis of Prescriptions Containing Ginseng in Treatise on Febrile and Miscellaneous Diseases

作　　者：孙秀丽 刘洁[1] 周庆莹 SUN Xiu-li;LIU Jie;ZHOU Qing-ying(School of Medical Information,School of Basic Medical Sciences,Changchun University of Chinese Medicine,Changchun 130117,Jilin,China;Jinkui Teaching and Research Section,School of Basic Medical Sciences,Changchun University of Chinese Medicine,Changchun 130117,Jilin,China)

机构地区：[1]长春中医药大学医药信息学院,吉林长春130117 [2]长春中医药大学基础医学院金匮教研室,吉林长春130117

出　　处：《医学信息》2021年第9期162-167,共6页Journal of Medical Information

基　　金：吉林省教育厅“十三五”科学技术项目(编号:JJKH20181274KJ)。

摘　　要：目的挖掘《伤寒杂病论》中含人参方剂的用药规律。方法以“人参”“山参”等不同人参名称为关键词,检索《中华医典》(第五版)中汉代中医古籍,收集含有人参的方剂,分析方剂的药味分布特征、药物出现频率,构建药物-药物关联网络和药物-方剂关联网络,对药物-药物关联网络进行图聚类分析。结果最终收集方剂53首,方剂含药物最多23味,最少3味,75%集中在7味及以下,《金匮要略方论》组总体上方剂含药味更多,分布更分散(3~23味),《伤寒论》组方剂含药味数较少,且分布相对集中(4~12味);所有方剂均为内服方剂,功能主治涉及内科、妇科和产科等各科病症;高频药物有大枣、生姜、半夏、干姜、炙甘草和桂枝,高频药组有{大枣,生姜,黄芩};有15条有效的关联规则和20条置信度为1的关联规则,方剂中有35条相对稳定的药物搭配规律;药物药性比例依次为寒>温>平>凉>热,药味比例依次为苦>辛>甘>咸>酸>淡,药物归经比例依次为胃经=脾经=肺经>肝经>肾经>心经>大肠经>膀胱经>胆经>小肠经>心包经。结论中医古籍中含有人参的方剂用药规律明显,既有明显的高频药物、药对和药组,又有诸多有效的关联规则,张仲景在随病症变化应用人参的过程中存在一定的配伍规律。另外,《金匮要略方论》与《伤寒论》各自具有明显的用药规律。Objective To explore the prescription rules of ginseng in Treatise on Febrile Diseases.Methods Using different ginseng names such as"ginseng"and"mountain ginseng"as keywords,search the Chinese Medical Dictionary(Fifth Edition)of ancient Chinese medicine books in the Chinese and Han dynasties,collect prescriptions containing ginseng,analyze the flavor distribution characteristics of the prescriptions,and the frequency of occurrence of the drugs.Construct a drug-drug association network and a drug-prescription association network,and perform graph cluster analysis on the drug-drug association network.Results In the end,53 prescriptions were collected.The prescriptions contained at most 23 flavors and at least 3 flavors.75%of them were concentrated in 7 flavors and below.The Golden Chamber Synopsis Formulas group contains more medicinal flavors and the distribution was more dispersed(3~23 flavors),while the"Treatise on Febrile Diseases"formula contained fewer medicinal flavors,and the distribution was relatively concentrated(4-12 flavors);All prescriptions were oral prescriptions,and their functions were mainly related to internal medicine,gynecology and obstetrics.The high-frequency drugs included jujube,ginger,pinellia,dried ginger,licorice and cassia twig,and the high-frequency drug group included{Jujube,Ginger,scutellaria};There were 15 effective association rules and 20 association rules with a confidence of 1,and there were 35 relatively stable drug combination rules in the prescription;The drug-to-activity ratio of the drug was in order of cold>warm>flat>cool>hot,the proportion of medicinal taste was bitter>pungent>sweet>salty>sour>light.The proportion of medicines returning to the meridian was stomach meridian=spleen meridian=lung meridian>liver meridian>kidney meridian>heart meridian>large intestine meridian>bladder meridian>biliary meridian>small intestine meridian>pericardial meridian.Conclusion The prescriptions containing ginseng in ancient Chinese medicine have obvious rules.There are not only obvious

关 键 词：人参 古籍方剂 伤寒论 金匮要略方论 

分 类 号：R222[医药卫生—中医基础理论]