高迁移率族蛋白B1在肿瘤中的双重作用  

Dual role of high mobility group box 1(HMGB1)in tumor progression

作　　者：陈玥琪 苏兆亮[1] 夏琳 Chen Yueqi;Su Zhaoliang;Xia Lin(International Genome Center,Jiangsu University,Zhenjiang 212013,China;Department of Laboratory Medicine,Affiliated Hospital of Jiangsu University,Zhenjiang 212001,China)

机构地区：[1]江苏大学国际基因组学研究中心,镇江212013 [2]江苏大学附属医院检验科,镇江212001

出　　处：《中华微生物学和免疫学杂志》2021年第3期221-225,共5页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金(81902136);中国博士后科学基金(2019M660106);镇江市科技计划(社会发展)(SH2018027)。

摘　　要：高迁移率族蛋白B1(high mobility group box 1,HMGB1)是广泛存在于真核细胞核染色质中的一种非组蛋白,在机体炎症性疾病、自身免疫病以及癌症中发挥重要作用。在肿瘤的发生发展中,不同亚细胞定位的HMGB1发挥不同的功能。一方面,HMGB1能够促进肿瘤细胞的生长、增殖、侵袭和转移,介导免疫逃逸与免疫耐受;另一方面,HMGB1能维持基因组稳定性,调节抑癌基因表达,抑制细胞侵袭与转移,提高抗肿瘤治疗功效,从而实现抗肿瘤作用。越来越多的研究表明HMGB1与肿瘤发生发展有着密切的联系,明确HMGB1的功能将为肿瘤的预防与治疗提供启示,本文主要围绕HMGB1在肿瘤发展中的双重作用进行综述。High mobility group box 1(HMGB1),a ubiquitous non-histone protein in the nuclear chromatin of eukaryotic cells,plays an important role in inflammatory diseases,autoimmune diseases and cancer.The function of HMGB1 in the development and progression of tumor varies with its subcellular localization.On one hand,HMGB1 promotes the growth,proliferation,invasion and metastasis of tumor cells,and mediates immune escape and immune tolerance;on the other hand,HMGB1 possesses anti-tumor activity by maintaining the stability of genome,regulating the expression of tumor suppressor genes,inhibiting cell invasion and metastasis and improving the anti-tumor therapeutic effect.In recent years,increasing evidences have suggested that HMGB1 is closely associated with the development of tumor.Therefore,understanding the function of HMGB1 in cancer will provide enlightenment for preventive and therapeutic strategies.This review summarized the dual role of HMGB1 in tumor progression.

关 键 词：高迁移率族蛋白B1 双重作用 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]