非小细胞肺癌患者外周血MAGE-A3基因表达及其与临床病理特征相关性分析  

Correlation between expression of MAGE-A3 gene in peripheral blood and clinicopathological features in patients with non-small cell lung cancer

作　　者：于鹏 李悟[1] 王忠华[1] 王卫东[1] 沈会华[1] 邢国柱[1] 袁源[1] YU Peng;LI Wu;WANG Zhonghua;WANG Weidong;SHEN Huihua;XING Guozhu;YUAN Yuan(Xinjiang Military Region General Hospital,Xinjiang Urumchi 830000,China)

机构地区：[1]新疆军区总医院,新疆乌鲁木齐830000

出　　处：《现代肿瘤医学》2021年第9期1510-1513,共4页Journal of Modern Oncology

摘　　要：目的:探讨非小细胞肺癌患者外周血黑色素瘤相关抗原(MAGE-A)3基因表达及其与临床病理特征的相关性。方法:选择2014年01月至2014年12月在我院就诊的137例非小细胞肺癌患者作为观察组,取同期在我院健康体检者57例作为对照组,采用RT-PCR检测受试者外周血MAGE-A3基因表达水平。分析非小细胞肺癌患者MAGE-A3表达与临床病理特征的相关性。结果:观察组MAGE-A3基因阳性率显著高于对照组,差异有统计学意义(P<0.05)。MAGE-A3基因表达与非小细胞肺癌患者性别、年龄、吸烟、病理类型均无相关性(P>0.05);低分化非小细胞肺癌患者MAGE-A3基因表达高于中高分化,Ⅲ-Ⅳ期患者表达高于Ⅰ-Ⅱ期,肿瘤≥5 cm患者表达高于<5 cm患者,淋巴结转移患者表达高于非转移患者,远处转移患者高于非转移患者,差异均有统计学意义(P<0.05)。结论:MAGE-A3基因在非小细胞肺癌患者外周血中阳性率升高,在晚期和转移患者中表达高于早期肺癌,有成为新的肿瘤预后判定指标的潜力。Objective:To investigate the correlation between the expression of MAGE-A3 gene in peripheral blood and the clinicopathological features of patients with non-small cell lung cancer.Methods:A total of 137 patients with non-small cell lung cancer who were admitted to our hospital from January 2014 to December 2014 were enrolled as the observation group.57 subjects who underwent physical examination in our hospital were used as the control group.The expression level of MAGE-A3 gene in peripheral blood of the subjects was detected by RT-PCR.The relationship between MAGE-A3 expression and clinicopathological features were observed in non-small cell lung cancer patients.Results:The positive rate of MAGE-A3 in the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).There was no difference in the expression of MAGE-A3 between gender,age,smoking,pathological type in non-small cell lung cancer patients(P>0.05).The expression of MAGE-A3 in patients with poorly differentiated cancer was higher than that in moderate to well differentiation.The expression of patients with stageⅢ-Ⅳwas higher than that of stageⅠ-Ⅱ.The expression of patients with tumor≥5 cm was higher than that of patients with<5 cm.The expression of lymph node metastasis was higher than that of non-metastatic patients.The expression of patients with distant metastasis was higher than non-distant metastatic patients,and the difference was statistically significant(P<0.05).Conclusion:The positive rate of MAGE-A3 in lung cancer patients was increased which is higher in advanced stage and metastatic patients than early stage patients.It has the potential to become a new indicator of tumor prognosis.

关 键 词：非小细胞肺癌 临床病理特征 黑色素瘤相关抗原 

分 类 号：R734.2[医药卫生—肿瘤]