卵巢子宫内膜异位囊肿剥离术后囊肿复发与否对接受IVF-ET治疗疗效的影响  

Effect of cyst recurrence after ovarian endometriosis cyst dissection on the efficacy of IVF-ET treatment

作　　者：许华玲 黄柯臻 黄晓兰 XU Hualing;HUANG Kezhen;HUANG Xiaolan(Department of Gynecology,the 174th Hospital of the People's Liberation,Fujian Xiamen 361000,China;Department of Reproductive Medicine,the 174th Hospital of the People's Liberation,Fujian Xiamen 361000,China)

机构地区：[1]中国人民解放军第一七四医院妇科,福建厦门361000 [2]中国人民解放军第一七四医院生殖科,福建厦门361000

出　　处：《现代肿瘤医学》2021年第9期1579-1583,共5页Journal of Modern Oncology

摘　　要：目的:探讨卵巢子宫内膜异位囊肿剥离术后囊肿复发与否对IVF-ET治疗疗效的影响。方法:选取2016年01月至2018年12月在我院妇产科生殖中心就诊,有过一次卵巢子宫内膜异位囊肿剥离术史、准备接受IVF-ET治疗的92例患者,根据术后囊肿是否复发分为复发组41例,未复发组51例。分别比较两组患者体质量指数、卵泡刺激素、促黄体素、雌二醇、窦卵泡计数、Gn启动量、Gn总使用量、hCG注射日内膜厚度、成熟卵泡个数、E2水平、获卵数、MII卵数、卵裂数、优质胚胎率、临床妊娠率、胚胎着床率、早期流产率、活产率、周期取消率等指标。结果:复发组患者hCG注射日成熟卵泡个数明显少于未复发组(P<0.05),两组之间Gn启动量、Gn总使用量、hCG日内膜厚度、hCG日E2水平以及IVF率、ICSI率均无明显差异(P>0.05)。复发组患者获卵数、MII卵数、卵裂数、优质胚胎率均明显低于未复发组,而周期取消率明显高于未复发组(P<0.05),两组患者胚胎着床率、临床妊娠率、早期流产率、活产率无明显差异(P>0.05)。结论:卵巢子宫内膜异位囊肿剥离术后囊肿复发对于不孕患者有不良影响,但是经IVF-ET治疗后,依然可以得到与非复发组患者相似的临床活产率,临床需个体化选择治疗方案。Objective:To investigate the effect of cyst recurrence after ovarian endometriosis cyst dissection on the efficacy of IVF-ET treatment.Methods:From January 2016 to December 2018,82 patients with ovarian endometriosis cyst who had been treated by IVF-ET in the reproductive center of obstetrics and gynecology of our hospital were selected.According to the recurrence of cyst after operation,41 patients were divided into recurrence group and 51 patients in non-recurrence group.Body mass index,follicle stimulating hormone,luteinizing hormone,estradiol,sinus follicle count,Gn initiation,total Gn usage,endometrial thickness per day of hCG injection,number of mature follicles,E2 level,number of eggs captured,number of MII eggs,cleavage,high quality embryo rate,clinical pregnancy rate,embryo implantation rate,early abortion rate,live birth rate and cycle cancellation rate were compared between the two groups.Results:The number of mature follicles on the day of hCG injection in the relapsed group was significantly less than that in the non-relapsed group(P=0.05).There were no significant differences in the amount of Gn initiation,total Gn usage,intimal thickness,E2 level on the day of hCG,IVF rate and ICSI rate between the two groups(P>0.05).The number of eggs obtained,the number of MII eggs,cleavage and the rate of high quality embryos in the relapsed group were significantly lower than those in the non-relapsed group,while the rate of cycle cancellation was significantly higher than that in the non-relapsed group(P=0.05).There was no significant difference in the implantation rate,clinical pregnancy rate,early abortion rate and live birth rate between the two groups(P>0.05).Conclusion:Cyst recurrence after ovarian endometriosis cyst exfoliation has adverse effects on infertility patients,but after IVF-ET treatment,similar clinical live birth rates can still be obtained in non-recurrence patients,and individualized treatment options are needed.

关 键 词：卵巢子宫内膜异位症 卵巢子宫内膜异位囊肿 囊肿复发 IVF-ET 

分 类 号：R737.31[医药卫生—肿瘤]