微生物代谢黄曲霉毒素B_(1)的研究进展  

Research Progress on the Microbial Metabolism of Aflatoxin B_(1)

作　　者：宋川 王利娟[4] 汪玲玲[1,2,3,4] SONG Chuan;WANG Lijuan;WANG Lingling(Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms,College of life sciences,South China Agricultural University,Guangzhou 510642,China;Key Laboratory of Zoonosis of Ministry of Agriculture and Rural Affairs,South China Agricultural University,Guangzhou 510642,China;Guangdong Laboratory for Lingnan Modern Agriculture,South China Agricultural University,Guangzhou 510642,China;College of Life Sciences,South China Agricultural University,Guangzhou 510642,China)

机构地区：[1]广东省农业生物蛋白质功能与调控重点实验室,生命科学学院,华南农业大学,广东广州510642 [2]农业部人畜共患病重点实验室,华南农业大学,广东广州510642 [3]岭南现代农业科学和技术广东省实验室,华南农业大学,广东广州510642 [4]华南农业大学生命科学学院,广东广州510642

出　　处：《食品工业科技》2021年第10期362-369,共8页Science and Technology of Food Industry

基　　金：国家自然科学基金(31600102);广州市科技计划(20180401020)。

摘　　要：黄曲霉毒素是由黄曲霉、寄生曲霉等真菌产生的次级代谢产物,主要存在于谷类、花生、玉米等农作物中。在我国尤其是南方省份,受高温高湿环境的影响,黄曲霉毒素在农作物上的污染极易发生,造成巨大的经济损失。利用微生物代谢黄曲霉毒素,具有专一、高效、反应条件温和等诸多优点,是目前公认的理想脱毒方法。本文首先简要介绍了黄曲霉毒素B_1的形成过程、结构特征以及毒性基团,接着重点介绍了已报道的能代谢黄曲霉毒素B_1的微生物种类、关键酶以及代谢途径,最后列举了应用基础研究的例子。Aflatoxin,the secondary metabolites mainly produced by Aspergillus flavus and Aspergillus parasite,are the most commonnatural food contaminants in cereals,peanuts and corn.In southern China,aflatoxin contamination in crops is extremely severe under the humid and hot climate,which lead to substantial economic losses.Applying the strategy of microorganism biodegradation of aflatoxinis currently an ideal detoxification approach with highspecificity and efficiency and mild reaction conditions.Here,a brief review is presented to introduce the formation,structural characteristics andtoxic groups of aflatoxin B1.We focus on microorganism biodegradation of aflatoxin B1,introducing the key microorganisms,enzymes,metabolic pathways and practical application for biodegradation.

关 键 词：黄曲霉毒素B_(1) 微生物 关键酶 代谢途径 

分 类 号：R285[医药卫生—中药学]