复方苦参注射液联合新辅助化疗对宫颈癌患者CA125、CA199、CEA的影响  

Effects of Compound Kushen Injection Combined with Neoadjuvant Chemotherapy on CA125,CA199 and CEA in Patients with Cervical Cancer

作　　者：印海娟 郑杰 董涛[2] 姬钰滢 徐建余 YIN Haijuan;ZHENG Jie;DONG Tao;JI Yuying;XU Jianyu(Graduate School,North China University of Science and Technology,Tangshan 063000,China;Qinhuangdao City The First Hospital;College of Life Sciences,North China University of Science and Technology)

机构地区：[1]华北理工大学研究生院,河北唐山063000 [2]秦皇岛市第一医院 [3]华北理工大学生命科学学院

出　　处：《西部中医药》2021年第4期105-108,共4页Western Journal of Traditional Chinese Medicine

基　　金：秦皇岛市科技计划项目(201805A022)。

摘　　要：目的:探讨复方苦参注射液联合新辅助化疗治疗宫颈癌的疗效及对血清糖类抗原125(carbohydrate antigen 125,CA125)、糖类抗原199(cancer antigen 199,CA199)、癌胚抗原(carcinoembryonic antigen,CEA)的影响。方法:选择宫颈癌患者102例,按随机数字表法分为对照组(50例)和观察组(52例)。对照组采用新辅助化疗治疗,观察组在对照组治疗基础上加用复方苦参注射液治疗。连续治疗2个疗程后,比较两组临床疗效、血清肿瘤标志物、免疫功能、毒副反应。结果:总缓解率观察组为88.46%(46/52),高于对照组的72.00%(36/50),差异有统计学意义(P<0.05)。治疗后,观察组CA125、CA199及CEA水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组CD4^(+)、CD3^(+)、CD4^(+)/CD8^(+)水平高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05)。观察组肾功能损伤、胃肠道反应、白细胞减少及脱发等不良反应发生率低于对照组,差异有统计学意义(P<0.05);两组骨髓抑制发生率相比,差异无统计学意义(P>0.05)。结论:采用复方苦参注射液联合新辅助化疗治疗宫颈癌可降低血清肿瘤标志物水平,提高机体免疫功能,减轻新辅助化疗的毒副反应。Objective:To explore clinical effects of compound Kushen injection and neoadjuvant chemotherapy in treating cervical cancer and its influence on the levels of CA125,CA199 and CEA.Methods:All 102 patients were divided into the control group(50 cases)and the observation group(52 cases)using random number table method.The control group adopted neoadjuvant chemotherapy,and the observation group were treated by compound Kushen injection based on Western medicine.To compare clinical effects,serum tumor markers,immunological function,toxic and adverse reaction between both groups when they were treated for two courses consecutively.Results:Total remission rate of the observation group was 88.46%(46/52),higher than 72.00%(36/50),and the difference showed statistical meaning(P<0.05).After treating,the observation group was lower than the control group in the levels of CA125,CA199 and CEA,and the difference was statistically significant(P<0.05).After the treatment,the levels of CD4^(+).CD3^(+).CD4^(+)/CD8^(+)of the observation group were higher than these of the control group,the levels of CD8^(+)lower than that of the control group,and the difference had statistical meaning(P<0.05).The observation group was lower than the control group in incidence of adverse reaction such as renal impairment,gastrointestinal reaction,leukocytopenia,alopecia,etc and the difference showed statistical meaning(P<0.05);the difference showed no statistical meaning in bone marrow suppression incidence between both groups(P>0.05).Conclusion:For patients with cervical cancer,compound Kushen injection combined with neoadjuvant chemotherapy could lower the levels of serum tumor markers,raise body immunological function and alleviate toxic and adverse reaction caused by neoadjuvant chemotherapy.

关 键 词：宫颈癌 复方苦参注射液 新辅助化疗 血清肿瘤标志物 免疫功能 

分 类 号：R737.3[医药卫生—肿瘤]