长期口服奥美拉唑引起灼口综合征样症状6例临床分析及文献回顾  

Clinical analysis and literature review of 6 cases of burning mouth syndromelike symptoms caused by the longterm oral administration of omeprazole

作　　者：路莹 颜启璋 于大海[2] LU Ying;YAN Qizhang;YU Dahai(College&Hospital of Stomatology,Guangxi Medical University,Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction,Guangxi Clinical Research Center for Craniofacial Deformity,Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment,Guangxi Zhuang Autonomous Region,Nanning 530021,China;Department of Stomatology,First Affiliated Hospital of Guangxi Medical University,Guangxi Zhuang Autonomous Region,Nanning 530021,China)

机构地区：[1]广西医科大学口腔医学院/附属口腔医院,广西口腔颌面修复与重建研究自治区级重点实验室,广西颅颌面畸形临床医学研究中心,颌面外科疾病诊治研究重点实验室(广西高校重点实验室),广西壮族自治区南宁530021 [2]广西医科大学第一附属医院口腔科,广西壮族自治区南宁530021

出　　处：《口腔疾病防治》2021年第8期553-556,共4页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：广西自然科学基金项目(2016GXNSFDA380002)。

摘　　要：目的分析奥美拉唑引起的灼口综合征样不良反应,为临床合理用药提供参考。方法收集2019年1月至2020年6月于广西医科大学第一附属医院就诊的关于奥美拉唑引起灼口综合征样改变的6例临床病例,并结合相关文献进行回顾性分析。结果在6例患者中,口服奥美拉唑时间最短6个月,最长超过5年,引起的灼口综合征样症状主要为口腔烧灼感,舌部感觉异常,可伴有肢端麻木,患者停服奥美拉唑,给予补充维生素及微量元素治疗,对症治疗1个月至半年后症状基本消失。文献回顾表明其原因可能与奥美拉唑引起外周神经或中枢神经损伤、改变唾液成分及妨碍维生素及微量元素摄入有关。结论奥美拉唑引起灼口综合征样症状原因可能为药物导致的神经损伤、唾液性状改变等,其主要处理方法为停药及对症治疗。Objective To analyze the oral adverse drug reactions induced by omeprazole and provide a reference for rational clinical drug use.Methods From January 2019 to June 2020,the clinical data of patients with burning mouth syndrome caused by omeprazole were collected and analyzed.Additionally,the related literature was reviewed.Results Among the six patients,omeprazole was taken orally for as little as 6 months and as long as more than 5 years.The symptoms of burning mouth syndrome were mainly burning sensation in the mouth and paresthesia on the tongue that might be accompanied by extremity numbness.Vitamin and trace element supplementation was administered.The patient discontinued omeprazole,and symptoms disappeared after symptomatic treatment for 1 month to half a year.Literature review suggests that the reason may be associated with peripheral or central nervous system injury,altered saliva composition,and impaired vitamin and micronutrient intake caused by omeprazole.Conclusion The cause of burning mouth syndromelike symptoms may be related to peripheral nerve injury caused by omeprazole and saliva changes.The main treatment is withdrawal and symptomatic treatment.

关 键 词：奥美拉唑 灼口综合征 不良反应 感觉异常 周围神经损伤 肢端麻木 

分 类 号：R781.5[医药卫生—口腔医学]