快速尿素酶和组织病理学检测幽门螺杆菌的价值分析  

Value Analysis on Rapid Urease Test and Histopathological Detection of Helicobacter Pylori

作　　者：范建华 吴瑾 FAN Jian-hua;WU Jin(Huangpu Branch of the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University Medical School,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院黄浦分院消化内科,上海200011

出　　处：《药物生物技术》2021年第1期26-29,共4页Pharmaceutical Biotechnology

基　　金：上海市黄浦区科研项目(No.HKM201808)。

摘　　要：分析快速尿素酶与组织病理学检测幽门螺杆菌(HP)的阳性率。2305例患者行电子胃镜检查,并对其中102例患者应用快速尿素酶试验与组织病理学两项检测方法检测幽门螺杆菌,对两种检测方法所得HP结果进行分析。幽门螺杆菌阳性率在性别、年龄组间无显著性差异,不同疾病组间消化性溃疡患者幽门螺杆菌(HP)检出率较高。102例患者中,两种方法结果一致78例(76.5%),不一致24例(23.5%)。单独运用快速尿素酶或组织病理学检测HP,易受患者用药史、胃镜下取材部位、试验条件等影响,二者联合可提高准确度。快速尿素酶检测HP方便实用,值得推广。Clinical medicine believes that Helicobacter pylori( HP) infection is closely related to chronic active gastritis,peptic ulcer,gastric cancer and MALT lymphoma. HP infection will lead to inflammation of the gastric mucosa of patients,leading to gastritis and ulcer,and then various inflammatory factors and harmful substances combined with the gastric mucosal epithelium,resulting in gastric mucosal damage and the possibility of intestinal metaplasia or intraepithelial neoplasia,which has been recognized as a precancerous lesion. It was reported that the incidence of gastric cancer in HP infection was up to 3%,indicating that HP could increase the incidence of gastric cancer in patients. In this context,HP was identified as a level I carcinogen. So the object of this research was to analyze the positive rate of rapid urease test and histopathological detection of HP. Retrospective analysis was conducted on the clinical data of 2 305 patients with digestive system diseases in Huangpu Branch of Shanghai Ninth People’ s Hospital from January 2019 to August 2020. These cases were examined by electronic gastroscopy,and in addition,the HP results obtained by rapid urease test and histopathology were analyzed in 102 patients who were tested for HP. There was no significant difference in the positive rate of HP in gender group and age group. Different diseases were grouped by gender( χ2= 5. 539,P = 0. 06) and by age( χ2= 13. 842,P = 0. 007),there were significant differences between different diseases grouped by age( P= 0. 007). The results were statistically treated by chi-square test. Among the 102 patients,the results of the two methods were consistent in 78 cases( 76. 5%) and inconsistent in 24 cases( 23. 5%). The sensitivity,specificity and accuracy of HP detection in102 patients were 89. 5%,64. 8% and 76. 5%. The accuracy was slightly higher than other relevant reports. Rapid urease test or histopathology alone can be used to detect HP,which was easily affected by the patient’ s medication history,gastroscope sa

关 键 词：幽门螺杆菌(HP) 快速尿素酶试验(RUT) 组织病理学 慢性胃炎 糜烂 消化性溃疡 

分 类 号：R573.9[医药卫生—消化系统]