托拉塞米与呋塞米治疗脑出血后急性脑水肿患者的临床效果  

Clinical Effects of Torasemide and Furosemide in the Treatment of Patients with Acute Cerebral Edema after Cerebral Hemorrhage

作　　者：姚奔驰 YAO Ben-Chi(The 463 Hospital of the People’s Liberation Army of Liaoning Province,Shenyang 110042,China)

机构地区：[1]解放军第四六三医院神经内科,沈阳110042

出　　处：《中国药物经济学》2021年第3期109-111,119,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨托拉塞米和呋塞米治疗脑出血后急性脑水肿患者的临床效果。方法选取2015年6月至2018年3月解放军第四六三医院收治的脑出血后急性脑水肿患者68例作为研究对象,随机分为观察组与对照组,每组34例。两组给予甘露醇、水、电解质与营养支持等基础治疗。对照组在基础治疗上给予呋塞米进行治疗,观察组在基础治疗上采用托拉塞米进行治疗,比较两组的治疗效果。结果治疗后,观察组患者脑水肿体积、血肿体积以及颅内压低于对照组,不良反应发生率明显低于对照组,治疗有效率明显高于对照组,差异有统计学意义(P<0.05)。观察组患者水肿消失时间、血肿清除时间短于对照组,差异有统计学意义(P<0.05)。两组治疗前格拉斯哥昏迷评分(GCS)评分比较差异无统计学意义(P>0.05);治疗后观察组GCS评分高于对照组,差异有统计学意义(P<0.05)。结论与呋塞米比较,采用托拉塞米治疗脑出血后急性脑水肿患者效果更好,能有效减少脑水肿体积与血肿体积,同时降低患者颅内压,减少并发症发生率,显著提高临床疗效。Objective To explore the clinical effects of torasemide and furosemide in the treatment of patients with acute cerebral edema after cerebral hemorrhage. Methods A total of of 68 patients with acute cerebral edema after intracerebral hemorrhage admitted to the 463 Hospital of the People’s Liberation Army was selected as the research objects and were randomly divided into an observation group and a control group with 34 cases in each group. Both groups were given basic treatments such as mannitol, water, electrolytes and nutritional support. The control group was treated with furosemide on the basic treatment, and the observation group was treated with torsemide on the basictreatment. Clinical efficacy of the 2 groups were compared. Results After treatment, the brain edema volume, hematoma volume, and intracranial pressure of the observation group were lower than those of the control group, the incidence of adverse reactions was significantly lower than that of the control group, and the treatment efficiency was significantly higher than that of the control group. The difference was statistically significant(P<0.05). The disappearance time of edema and hematoma clearance in the observation group were shorter than those in the control group, and the difference was statistically significant(P<0.05). There was no significant difference in GCS score between the 2 groups before treatment(P>0.05);after treatment, the GCS score of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). Conclusion Compared with furosemide, torasemide is more effective in treating patients with acute cerebral edema after intracerebral hemorrhage. It can effectively reduce the volume of their own brain edema and hematoma, and at the same time reduce the intracranial pressure of patients and reduce the occurrence of complications rate, and significantly improve clinical efficacy.

关 键 词：托拉塞米 呋塞米 脑出血 急性脑水肿 

分 类 号：R743.3[医药卫生—神经病学与精神病学]