尼麦角林对脑梗死患者认知功能、血液流变学及炎性标志物的影响  

Effects of nicergoline on cognitive function,hemorheology and inflammatory markers in patients with cerebral infarction

作　　者：林露 祁敏芳 LIN Lu;QI Minfang(Intensive Care Unit,Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,Taizhou 318050,China;Intensive Care Unit,Luqiao Hospital,Taizhou Enze Medical Center(Group),Taizhou 318050,China)

机构地区：[1]浙江省台州医院重症监护室,浙江台州318050 [2]台州恩泽医疗中心(集团)路桥医院重症监护室,浙江台州318050

出　　处：《健康研究》2021年第2期222-225,共4页Health Research

基　　金：台州市科技计划项目(XM20190579)。

摘　　要：目的观察脑梗死患者接受尼麦角林治疗后,其认知功能、血液流变学及炎性标志物的变化。方法100例脑梗死患者随机分为观察组和对照组各50例,观察组在常规治疗基础上加用尼麦角林治疗。治疗前及治疗2周后,采用蒙特利尔认知评估(MoCA)和简易智力状态检查量表(MMSE)评估患者认知功能情况;比较2组患者治疗前后血液流变学参数及血清炎症因子肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和C反应蛋白(CRP)水平的变化;记录患者治疗过程中不良反应发生情况。结果治疗前,2组MoCA评分和MMSE评分差异无统计学意义(P>0.05);治疗后,2组MoCA评分和MMSE评分均升高,观察组高于对照组,差异有统计学意义(P<0.05)。治疗前,2组血液流变学参数水平和TNF-α、IL-6、CRP水平差异无统计学意义(P>0.05);治疗后,2组上述指标均下降,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗过程中,观察组的不良反应总发生率(10.00%)与对照组(14.00%)差异无统计学意义(χ2=0.379,P=0.538)。结论常规治疗加用尼麦角林可显著改善脑梗死患者的认知功能,具有较好的临床疗效,并可调节血液流变学参数水平,抑制炎症反应,安全性较好。Objective To observe the changes of cognitive function,hemorheology,and inflammatory markers in patients with cerebral infarction after treatment with nicergoline.Methods 100 patients with cerebral infarction were randomly divided into an observation group(n=50)and a control group(n=50).The observation group was additionally treated with nicergoline based on conventional treatment.MoCA and MMSE were used to evaluate the cognitive function of the patients before and two weeks after treatment.The changes in hemorheological parameters and serum levels of TNF-α,IL-6,and CRP were compared between the two groups before and after treatment.The incidence of adverse reactions during treatment was recorded.Results Before treatment,there was no significant difference between the two groups in MoCA score and MMSE score(P>0.05).After treatment,MoCA score and MMSE score of the two groups increased,and the observation group were higher than the control group,the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in hemorheological parameters and TNF-α,IL-6,CRP levels between the two groups(P>0.05).After treatment,hemorheological parameters and TNF-α,IL-6,CRP levels of the two groups decreased,and the observation group were lower than the control group,the differences were statistically significant(P<0.05).During the treatment,there was no significant difference in the total incidence of adverse reactions between the observation group(10.00%)and the control group(14.00%)(χ2=0.379,P=0.538).Conclusions Conventional treatment with nicergoline can significantly improve the cognitive function of patients,has good clinical efficacy,and can regulate the level of hemorheological parameters,inhibit the inflammatory response,with good safety.

关 键 词：尼麦角林 脑梗死 认知功能 血液流变学 炎症因子 

分 类 号：R743[医药卫生—神经病学与精神病学]