破囊壶菌生产角鲨烯的研究现状  

Research Status in the Production of Squalene by Thraustochytrids

作　　者：李梦凡 谢云轩 谢宁栋 张爱卿 汪光义[1] LI Meng-fan;XIE Yun-xuan;XIE Ning-dong;ZHANG Ai-qing;WANG Guang-yi(School of Environmental Science and Engineering,Tianjin University,Tianjin 300072)

机构地区：[1]天津大学环境科学与工程学院,天津300072

出　　处：《生物技术通报》2021年第4期234-244,共11页Biotechnology Bulletin

摘　　要：角鲨烯是一种重要的多不饱和三萜类物质,能参与人体内多个生理过程,具有增强机体免疫、延缓皮肤衰老、防癌等功效。破囊壶菌在异养条件下能够快速生长并合成较高含量的角鲨烯,具有开发生产角鲨烯的应用潜力。首先概述了破囊壶菌的生态学和生物技术应用潜力,重点讨论了利用破囊壶菌生产角鲨烯的研究现状,并对破囊壶菌合成角鲨烯的代谢途径进行了总结;然后,对影响破囊壶菌发酵生产角鲨烯的5个主要因素进行了综述,并总结了激素类物质对破囊壶菌角鲨烯产量的调控作用。对上述一系列问题的阐述旨在为利用破囊壶菌产角鲨烯的进一步研究开发提供参考。Squalene is an important polyunsaturated triterpene substance,participates in multiple physiological processes in human body,and has the effect of enhancing immunity,delaying skin aging,and preventing the cancer.Under heterotrophic conditions,Thraustochytrids can grow rapidly and synthesize high content of squalene,thus there is the potential of developing industrial production of squalene.In this paper,the application potential of ecology and biotechnology of Thraustochytrids were outlined,focusing on the research status of squalene production by Thraustochytrids,and the metabolic pathways of squalene synthesis by Thraustochytrids were summarized.Then,five main factors affecting the production of squalene in the fermentation of Thraustochytrids were reviewed,and the regulatory effects of hormone substances on the production of squalene by Thraustochytrids were summarized.The aim of this review is to provide reference for the further research and development of squalene production by Thraustochytrids.

关 键 词：破囊壶菌 角鲨烯 影响因素 代谢通路 激素 

分 类 号：TQ920.1[轻工技术与工程—发酵工程] Q936[生物学—微生物学]