乳腺髓样癌与浸润性导管癌的临床病理特征及预后比较  

Comparison of Clinicopathological Features and Prognosis of Medullary Breast Carcinoma and Invasive Ductal Carcinoma

作　　者：张玉杰[1] 王新星[1] 薛兵建 孙萌 李凯强 张亚娜[1] 裴新红[1] ZHANG Yujie;WANG Xinxing;XUE Bingjian;SUN Meng;LI Kaiqiang;ZHANG Yana;PEI Xinhong(Department of Breast Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院乳腺外科,河南郑州450052

出　　处：《河南医学研究》2021年第9期1555-1559,共5页Henan Medical Research

基　　金：河南省高等学校重点科研项目(18A320017)。

摘　　要：目的比较乳腺髓样癌(MBC)与浸润性导管癌(IDC)的临床病理特征及预后特点。方法回顾性分析2012年1月至2018年6月郑州大学第一附属医院收治的31例MBC患者的临床病理资料,包括发病年龄、病灶大小、组织学分级、雌激素受体(ER)状态、孕激素受体(PR)状态、人表皮生长因子2(HER 2)受体状态、Ki-67增殖指数、P53表达情况、分子分型、上皮细胞钙黏蛋白(E-cadherin)、脉管浸润情况(LVI)、淋巴结状态、患者的复发转移及生存情况等,并与同期收治的104例IDC患者进行对比。结果MBC患者的ER、PR、HER 2受体状态和E-cadherin表达情况与IDC患者相比,差异有统计学意义(P<0.05)。MBC患者病灶大小、Ki-67增殖指数和P53情况与IDC组相比,差异无统计学意义(P>0.05)。MBC患者组织学分级、分子分型、脉管浸润和淋巴结状态与IDC患者相比,差异有统计学意义(P<0.05)。MBC和IDC患者的5年无病生存率分别为82.8%和92.2%,差异无统计学意义(P>0.05)。MBC和IDC患者的5年总生存率分别为87.5%和94.4%,差异无统计学意义(P>0.05)。结论MBC是一种少见的乳腺癌亚型,尽管病理学特征表现较差,但其预后未必差于IDC。Objective To investigate the clinicopathological features and prognosis of medullary breast carcinoma(MBC)and invasive ductal carcinoma(IDC).Methods The clinicalpathological data of 31 patients with MBC admitted to the First Affiliated Hospital of Zhengzhou University from January 2012 to June 2018 were retrospectively collected,including age,tumor size,histological grade,estrogen receptor(ER)status,progesterone receptor(PR)status,human epidermal growth factor receptor 2(HER 2),Ki-67 index,P53 status,molecular typing,E-cadherin expression,lymphovascular invasion(LVI),lymph node status,recurrence,metastasis and survival of patients,and compared with 104 cases of IDC patients treated at the same time.Results There were differences in the ER、PR、HER 2 receptor status and E-cadherin expression between MBC patients and IDC patients(P<0.05).There were no differences in the lesion size,Ki-67 index and P53 between MBC patients and IDC patients(P>0.05).There were differences in the histological classification,molecular type,vascular infiltration and lymph node status between MBC patients and IDC patients(P<0.05).The 5-year disease-free survival rates of MBC and IDC patients were 82.8%and 92.2%,respectively,and there was no difference in the 5-year disease-free survival rates between MBC and IDC patients(P>0.05).The 5-year overall survival rates of MBC and IDC patients were 87.5%and 94.4%,respectively,and there was no difference in the 5-year overall survival rates between MBC and IDC patients(P>0.05).Conclusion MBC is a rare subtype of breast cancer,and its prognosis is not necessarily worse than that of IDC,despite poor pathological features.

关 键 词：乳腺癌 髓样癌 浸润性导管癌 临床病理特征 预后 

分 类 号：R737.9[医药卫生—肿瘤]