老年胃癌患者血清转化生长因子-β_(1)、核转录因子-κB、热休克蛋白60水平与幽门螺旋杆菌感染的相关性研究  

Correlation between serum transforming growth factor-β_(1),nuclear transcription factor-κB,heat shock protein 60 levels and Helicobacter pylori infection in elderly patients with gastric cancer

作　　者：李延卿[1] 张岱[1] 张旭冉 顾亚娇[2] 任伟宏[1] LI Yanqing;ZHANG Dai;ZHANG Xuran;GU Yajiao;REN Weihong(Department of Laboratory,the First Affiliated Hospital,Henan University of Chinese Medicine,Zhengzhou 450000,China;Department of Spleen,Stomach,Liver and Gallbladder,the First Affiliated Hospital,Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院检验科,河南郑州450000 [2]河南中医药大学第一附属医院脾胃肝胆科,河南郑州450000

出　　处：《肿瘤基础与临床》2021年第1期24-28,共5页journal of basic and clinical oncology

基　　金：河南中医药基础研究专项课题(2019JDZX2090、2018JDZX065)。

摘　　要：目的探讨老年胃癌患者血清转化生长因子-β_(1)(TGF-β_(1))、核转录因子-κB(NF-κB)、热休克蛋白60(HSP60)水平与幽门螺旋杆菌(Hp)感染的相关性。方法选取2017年2月至2019年8月河南中医药大学第一附属医院收治的92例老年胃癌患者作为研究对象,比较不同临床病理特征患者血清TGF-β_(1)、NF-κB、HSP60水平,不同感染程度Hp感染患者与未感染患者血清TGF-β_(1)、NF-κB、HSP60水平,探讨血清TGF-β_(1)、NF-κB、HSP60水平与老年胃癌患者Hp感染的关系及三者对老年胃癌患者Hp感染的预测价值。结果老年胃癌患者血清TGF-β_(1)、NF-κB、HSP60水平与肿瘤直径、分化程度、浸润深度、TNM分期、淋巴结转移有关(P均<0.05)。不同Hp感染程度患者血清TGF-β_(1)、NF-κB、HSP60水平均高于未感染患者(P<0.05),且随Hp感染程度的增加,血清TGF-β_(1)、NF-κB、HSP60水平也随之升高。Logistic回归分析发现,随着血清TGF-β_(1)、NF-κB、HSP60水平升高,老年胃癌患者Hp感染风险逐渐升高(P均<0.05)。血清TGF-β_(1)、NF-κB、HSP60水平联合预测老年胃癌患者Hp感染的曲线下面积为0.870,大于各指标单一预测的0.805、0.761、0.816,联合预测的最佳敏感性、特异性分别为71.43%、86.67%。结论老年胃癌患者血清TGF-β_(1)、NF-κB、HSP60表达与患者临床病理特征关系密切,且各指标表达水平与患者Hp感染呈正相关,通过检测各指标表达水平有助于预测Hp感染风险。Objective To investigate the correlation between serum transforming growth factor-β_(1)(TGF-β_(1)),nuclear transcription factor-κB(NF-κB),heat shock protein 60(HSP60)levels and Helicobacter pylori(Hp)infection in elderly patients with gastric cancer.Methods From February 2017 to August 2019,92 elderly patients with gastric cancer in our hospital were selected as the research object.the serum TGF-β_(1),NF-κB and HSP60 levels in patients with different clinicopathological characteristicswere compared,and the serum TGF-β_(1),NF-κB and HSP60 levels in uninfected patients and Hp infected patients with different degrees of infectionwere compared,and the relationship between serum levels of TGF-β_(1),NF-κB,HSP60 and Hp infection in elderly gastric cancer patients and the predictive value of the three for Hp infection in elderly gastric cancer patients were analyzed.Results Serum TGF-β_(1),NF-κB,HSP60 levels in elderly gastric cancer patients were related to tumor diameter,degree of differentiation,depth of invasion,TNM stage,and lymph node metastasis(P<0.05).The levels of serum TGF-β_(1),NF-κB and HSP60 in patients with different levels of Hp infection were higher than those in uninfected patients(P<0.05),and with the increase of Hp infection,the levels of serum TGF-β_(1),NF-κB and HSP60 also increased.Logistic regression analysis found that with the increase of serum TGF-β_(1),NF-κB and HSP60 levels,the risk of Hp infection in elderly gastric cancer patients gradually increased(P<0.05).The area under the curve of serum TGF-β_(1),NF-κB,and HSP60 combined to predict Hp infection in elderly gastric cancer patients was 0.870,which was greater than the single predictions of 0.805,0.761,and 0.816,the best sensitivity and specificity of the joint prediction were 71.43%and 86.67%,respectively.Conclusion The expression of serum TGF-β_(1),NF-κB and HSP60 in elderly patients with gastric cancer is closely related to the clinicopathological characteristics of the patients,and the expression level of each inde

关 键 词：胃癌 转化生长因子-β_(1) 核转录因子-ΚB 热休克蛋白60 幽门螺旋杆菌感染 

分 类 号：R735.2[医药卫生—肿瘤]