腺苷酸激酶4在恶性肿瘤中的研究进展  

Research progress of adenylate kinase 4 in malignant tumors

作　　者：牛良晨(综述) 李力(审校)[1] Liangchen Niu;Li Li(Department of Gynecologic Oncology,Affiliated Tumor Hospital of Guangxi Medical University,Key laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Ministry of Education),Nanning 530021,China)

机构地区：[1]广西医科大学附属肿瘤医院妇瘤科,区域性高发肿瘤早期防治研究教育部重点实验室,南宁市530021

出　　处：《中国肿瘤临床》2021年第7期366-370,共5页Chinese Journal of Clinical Oncology

基　　金：广西科学研究与技术开发计划项目(编号:桂科攻1140003A-33)资助。

摘　　要：腺苷酸激酶4(adenylate kinase 4,AK4)是腺苷酸激酶家族的成员之一,具有调节细胞腺嘌呤核苷三磷酸(adenosine triphos⁃phate,ATP)浓度的生物学功能,在调节细胞能量代谢过程中起重要作用,同时也在缺氧耐受、肿瘤的发展、抗肿瘤药物耐药、调节线粒体活性等方面发挥重要作用。恶性肿瘤一直是严重威胁人类健康的疾病,许多肿瘤的死亡率居高不下。恶性肿瘤的发生、发展及治疗一直是科学研究的热点,肿瘤的治疗在不断改进,尽管在部分领域取得一定进展,但总体来说,我们对肿瘤的认识,尤其是治疗、耐药后治疗仍未突破瓶颈。AK4被用作抗癌治疗的潜在治疗靶点,而AK4与肿瘤之间的确切关系尚未得到进一步的阐明。本文拟对AK4的研究现状作一综述,以期对AK4及其在临床及疾病中的研究提供新思路。Adenylate kinase 4(AK4),a member of the adenylate kinase family,regulates the concentration of cellular ATP and plays a pivotal role in the regulation of energy metabolism in cells.It also plays a crucial role in hypoxia tolerance,tumor development,anti-tumor drug resistance,and regulation of mitochondrial activity.Malignant tumors are a serious threat to human health;the mortality rate associated with malignant tumors remains high.The occurrence,development,and treatment of malignant tumors have long been the prime focus of scientific research.Although tumor treatment is continuously improving and a steady progress is seen with regard to our understanding of tumors in general,no breakthroughs,especially the identification of therapeutic targets and strategies for the treatment of post-drug resistance,have been achieved.AK4 is a potential therapeutic target for anticancer therapy;however,the exact relationship between AK4 and tumor development has not yet been established clearly.In view of the ongoing progress and unmet challenges,this article intends to summarize the current status of research regarding AK4,aiming to provide novel ideas for clinical and disease-related studies regarding this aspect.

关 键 词：腺苷酸激酶4 恶性肿瘤 信号通路 能量代谢 

分 类 号：R730.2[医药卫生—肿瘤]