光热型超声造影剂用于治疗肿瘤研究进展  

Research progresses of photothermal ultrasoundcontrast agents for tumor therapy

作　　者：毛盈譞 董天秀[1] 张浩 朱明微 杨秀华[1] MAO Yingxuan;DONG Tianxiu;ZHANG Hao;ZHU Mingwei;YANG Xiuhua(Department of Abdominal Ultrasound,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院腹部超声科,黑龙江哈尔滨150001

出　　处：《中国医学影像技术》2021年第4期612-615,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(81871362)。

摘　　要：随着分子影像学和纳米技术的发展,可用于光热治疗的多功能超声造影剂(UCA)逐渐涌现。受近红外光触发后,光热型UCA可清晰显示肿瘤病灶,并可监控靶向热消融肿瘤。将光热剂整合于造影剂结构中,不仅提高了光热剂的稳定性,同时可协同超声空化效应增效光热治疗。本文针对光热型UCA用于治疗肿瘤的研究进展进行综述。With the advances of molecular imaging and nanotechnology,multifunctional ultrasound contrast agents(UCA)used for photothermal therapy are gradually emerging.Triggered by near-infrared light,photothermal UCA can both clearly show tumor lesions and achieve tumor-targeted thermal ablation under ultrasonic monitoring.Integrating the photothermal agent into contrast agent can not only improve the stability of the photothermal agent,but also obtain the ultrasonic cavitation effect to synergistically enhance the efficacy of photothermal treatment of tumors.The research progresses of photothermal UCA in treatment of tumors were reviewed in this article.

关 键 词：肿瘤 超声检查 造影剂 光热治疗 

分 类 号：R73[医药卫生—肿瘤] R445.1[医药卫生—临床医学]