PD-1/PD-L1通路在髓系肿瘤中的研究进展  

Research progress of PD-1 and PD-L1 pathway in myeloid haematopoietic malignancy

作　　者：王亚丽[1] 张丽军[2,3] 成志勇[2] 许广超 吴娜[4] 丁玉芝 周小代 WANG Yali;ZHANG Lijun;CHENG Zhiyong;XU Guangchao;WU Na;DING Yuzhi;ZHOU Xiaodai(Department of Nutriology,the No.1 Hospital of Baoding,Hebei Baoding 071000,China;Department of Hematology,the No.1 Hospital of Baoding,Hebei Baoding 071000,China;Graduate School of Chengde Medical University,Hebei Chengde 067000,China;Department of Hematology,Dingzhou People's Hospital,Hebei Dingzhou 073000,China)

机构地区：[1]保定市第一医院营养科,河北保定071000 [2]保定市第一医院血液内科,河北保定071000 [3]承德医学院研究生院,河北承德067000 [4]定州市人民医院血液内科,河北保定073000

出　　处：《现代肿瘤医学》2021年第10期1793-1797,共5页Journal of Modern Oncology

基　　金：河北省重点研发科技项目(编号:162777120D);保定市科技计划项目(编号:1851ZF046)。

摘　　要：在免疫系统中,为防止免疫反应过度,细胞表面会有抑制免疫反应的检查点,其中程序性死亡受体-1(programmed death-1,PD-1)与其程序性死亡配体-1(programmed death-ligand 1,PD-L1)就是其中的一对免疫检查点,肿瘤细胞通过表达PD-L1与免疫细胞上的PD-1受体结合,使得肿瘤细胞可以逃避免疫细胞的攻击。研究表明,PD-1及PD-L1在多种实体肿瘤组织及免疫细胞中存在过表达现象,导致抗肿瘤细胞功能消失,并且与不良预后相关,但在髓系肿瘤中的研究较少。因此本文从PD-1/PD-L1的生物学特点,目前在髓系肿瘤中的表达情况,以及传统化疗药物对该通路的作用作一综述,旨在为髓系肿瘤的诊疗提供新的靶点。In the immune system,the checkpoints that inhibit immune response on the surface of cells can prevent immune overreaction.Among them,programmed death-1(PD-1)and its ligand programmed death-ligand 1(PD-L1),are a pair of checkpoints.Tumor cells can escape the attack of immune cells by expressing PD-L1 and binding PD-1 receptors on immune cells.Studies have shown that PD-1 and PD-L1 are over expressed in a variety of solid tumor tissues and immune cells,leading to the disappearance of anti-tumor cell function,and related to poor prognosis,but there are few studies in myeloid haematopoietic malignancy.This article reviews the biological characteristics of PD-1/PD-L1,its expression in hematopoietic neoplasms and the interference of traditional chemotherapeutic agents on this pathway in order to provide new ideas for the diagnosis and treatment of hematopoietic neoplasms.

关 键 词：程序性死亡受体-1(PD-1) 程序性死亡配体-1(PD-L1) 髓系 肿瘤 

分 类 号：R733[医药卫生—肿瘤]