m^(6)A甲基化在肿瘤中修饰非编码RNA的最新研究进展  

Advances in non-coding RNA modified by m^(6)A in tumor

作　　者：易佑财 张靖[1] 陈晓宇[1] 朱金水[1] YI Youcai;ZHANG Jing;CHEN Xiaoyu;ZHU Jinshui(Department of Gastroenterology,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai 200233,China)

机构地区：[1]上海交通大学附属第六人民医院消化科,上海200233

出　　处：《现代肿瘤医学》2021年第10期1825-1828,共4页Journal of Modern Oncology

基　　金：国家自然科学基金面上项目(编号:81873143,81573747)。

摘　　要：非编码RNA(non-coding RNA,ncRNA)在细胞分化、血管生成、免疫应答、炎症反应以及肿瘤发生发展中具有重要作用。m^(6)A(N6-methyladenosine)甲基化是真核生物中最常见的RNA修饰方式之一,主要见于信使RNA(messenger RNA,mRNA)。m^(6)A甲基化修饰主要有三种酶参与完成,包括甲基转移酶、去甲基化酶和甲基化识别酶,并且在昼夜节律调控、基因表达、细胞分化、胚胎发育、应激反应及肿瘤发生中发挥作用。目前已有研究证实m^(6)A甲基化通过调控ncRNAs在肿瘤生长、侵袭和转移中具有重要作用。本文将对m^(6)A甲基化在肿瘤中修饰ncRNAs的最新研究进展进行综述。Non-coding RNAs(ncRNAs)play an important role in cell differentiation,angiogenesis,immune response,inflammatory response and tumor development and metastasis.m^(6)A(N6-methyladenosine)is one of the most common RNA modifications in eukaryotes,especially in messenger RNA(mRNA).m^(6)A methylation modification is mainly carried out by three enzymes,including methyltransferase,demethylase and methylated recognition enzyme,and acts a role in circadian rhythm regulation,gene expression,cell differentiation,embryonic development,stress response and tumorigenesis.At present,it has been confirmed that m^(6)A methylation acts in tumor growth,invasion and metastasis by regulating ncRNAs.In this paper,we will review the latest research progress about how m^(6)A methylation modifies ncRNAs in cancer.

关 键 词：m^(6)A甲基化 非编码RNA 肿瘤 

分 类 号：R73-34[医药卫生—肿瘤]