胆管树干细胞在肝脏和胰腺再生中的研究进展  

Biliary tree stem cells and their applications in liver and pancreas regeneration

作　　者：杨勇 时军[2,4] 何志颖[1,3] 张文成 YANG Yong;SHI Jun;HE Zhi-ying;ZHANG Wen-cheng(Institute of Regenerative Medicine,Shanghai East Hospital,School of Life Sciences and Technology,Tongji University,Shanghai 200123,China;Dept.of General Surgery,The First People's Hospital of Nanchang University,Nanchang 330006,China;Translational Medical Center for Stem Cell Therapy,Shanghai East Hospital,School of Medicine,Tongji University,Shanghai 200123,China;Dept.of General Surgery,Ji'an Hospital of Shanghai East Hospital,School of Medicine,Tongji University,Ji'an 343006,Jiangxi Province,China)

机构地区：[1]同济大学附属东方医院再生医学研究所,上海200123 [2]南昌大学第一附属医院普通外科,南昌330006 [3]同济大学附属东方医院干细胞转化医学产业基地,上海200123 [4]上海市东方医院吉安医院·同济大学附属东方医院吉安医院普外科,江西吉安343006

出　　处：《同济大学学报（医学版）》2021年第2期152-157,共6页Journal of Tongji University(Medical Science)

基　　金：国家重点研发计划(2019YFA0801502、2020YFA0112600);上海张江国家自主创新示范区专项发展资金重大项目(ZJ2018-ZD-004);上海市浦东新区高峰学科建设项目(PWYgf2018-04);上海市科委学术/技术带头人项目(20XD1434000)。

摘　　要：胆管树干细胞(biliary tree stem cells, BTSCs)是一类存在于胆管壁上胆周腺内的干细胞,具有分化为成熟肝细胞、胆管上皮细胞及胰腺内分泌细胞等类型细胞的多向分化潜能,在肝损伤治疗、糖尿病救治等方面具有巨大应用前景。本文结合胆管及其相关组织的胚胎发育过程、解剖学特征、BTSCs谱系分布特点及分子标志、体外扩增特性、基础及临床研究现状等,对BTSCs的生物学特性进行阐述,并对其在肝脏和胰腺器官再生中的研究进展和应用前景进行总结和展望。Biliary tree stem cells(BTSCs)are stem cells located in peribiliary glands on the bile ductal wall.These multipotent stem cells have potentials of differentiation into mature hepatocytes,cholangiocytes and pancreatic endocrine cells.Therefore,they might be used as candidate cell types for treating liver injury and diabetes.This review summaries the biological features of BTSCs,focusing on the embryonic development and anatomical features of the biliary tree and its related tissues,the lineage distribution of BTSCs,cell isolation and purification,in vitro expansion,and in vivo transplantation of BTSCs;and also discusses the prospects of their application in the regeneration of liver and pancreas.

关 键 词：胆管树干细胞 肝脏再生 胰腺再生 细胞谱系 

分 类 号：R575[医药卫生—消化系统] R575[医药卫生—内科学]