某医疗机构健康体检人群幽门螺杆菌感染情况及影响因素分析  

Analysis of Helicobacter pylori infection and its risk factors among health examination participants in a general hospital

作　　者：宋宇[1] 周芸竹 薛培丽[1] 蔡周权[1] 兰亚佳[2] SONG Yu;ZHOU Yunzhu;XUE Peili;CAI Zhouquan;LAN Yajia(Department of Health Management,Sichuan Science City Hospital,Mianyang,Sichuan 621000,P.R.China;Department of Occupational and Environmental Medicine,West China School of Public Health,Sichuan University,Chengdu,Sichuan 610041,P.R.China)

机构地区：[1]四川省科学城医院健康管理部,四川绵阳621000 [2]四川大学华西公共卫生学院环境卫生与职业医学系,成都610041

出　　处：《华西医学》2021年第4期493-498,共6页West China Medical Journal

基　　金：国家自然学科基金(81661148050)。

摘　　要：目的了解某医疗机构健康体检人群中幽门螺杆菌(Helicobacter pylori,Hp)感染现状并分析其影响因素,为制定Hp感染防治方案提供科学依据。方法回顾性分析2018年1月—12月在四川省科学城医院进行碳-13尿素呼气试验健康体检者的Hp感染情况,收集并整理体检结果。比较不同性别和年龄段Hp感染率差异,通过二分类logistic回归分析Hp感染的潜在危险因素。结果共纳入8093名研究对象,男5530人(68.33%),女2563人(31.67%)。Hp总体人群感染率为37.80%(3059/8093),其中男性感染率[39.48%(2183/5530)]明显高于女性[34.18%(876/2563)],差异有统计学意义(χ^(2)=20.899,P<0.001)。全体人群中50~59岁组的感染率最高(43.87%),<30岁组的感染率最低(30.93%),不同年龄组间Hp感染率的差异有统计学意义(χ^(2)=64.577,P<0.001)。男性[比值比(odds ratio,OR)=1.257,P<0.001]、40~49岁(OR=1.446,P<0.001)、50~59岁(OR=1.756,P<0.001)、60~69岁(OR=1.512,P<0.001)、高总胆固醇(OR=1.221,P=0.003)和肥胖(OR=1.403,P<0.001)是Hp感染的危险因素。结论该医疗机构健康体检人群Hp感染率低于我国平均水平,男性、40~69岁、高总胆固醇和肥胖是Hp感染的危险因素,应有针对性地采取措施预防和控制Hp感染。Objective To investigate and analyze the prevalence and influencing factors of Helicobacter pylori(Hp),to provide scientific basis for the development of Hp infection prevention and control program.Methods The Hp infection of healthy population who received 13C-urea breath test in Sichuan Science City Hospital from January to December 2018 were retrospectively analyzed.Medical examination reports were collected and sorted out.We compared the gender and age differences of Hp infection,and binary logistic regression analysis was performed to analyze the risk factors of Hp infection.Results A total of 8093 healthy participants were included,including 5530 males(68.33%)and 2563 females(31.67%).The infection rate of Hp was 37.80%(3059/8093)in all subjects.The infection rate of males[39.48%(2183/5530)]was significantly higher than that of females[34.18%(876/2563)](χ^(2)=20.899,P<0.001).The infection rate of 50-59 years old group was the highest(43.87%),and that of<30 years old group was the lowest(30.93%).The difference of Hp infection rate among different age groups was statistically significant(χ^(2)=64.577,P<0.001).Logistic regression analysis showed that male[odds ratio(OR)=1.257,P<0.001],40-49 years old(OR=1.446,P<0.001),50-59 years old(OR=1.756,P<0.001),60-69 years old(OR=1.512,P<0.001),high total cholesterol level(OR=1.221,P=0.003)and obesity(OR=1.403,P<0.001)were risk factors for Hp infection.Conclusions The prevalence of Hp infection in the general hospital is lower than the national average level,and male,40-69 years old,high total cholesterol level and obesity are predictors of Hp infection.Effective measures should be taken to prevent and control the infection of Hp.

关 键 词：幽门螺杆菌 感染率 危险因素 

分 类 号：R573[医药卫生—消化系统]