胶原蛋白肽分析方法及透皮吸收特征  

Analysis methods and transdermal absorption of collagen peptides

作　　者：化璟琳 谢莹莹 徐鹤然 张晓娜[1] 王敏[1] Hua Jinglin;Xie Yingying;Xu Heran;Zhang Xiaona;Wang Min(School of Chemistry and Materials Engineering,Beijing Technology and Business University,Beijing 100048,China)

机构地区：[1]北京工商大学化学与材料工程学院,北京市100048

出　　处：《中国组织工程研究》2021年第34期5544-5551,共8页Chinese Journal of Tissue Engineering Research

摘　　要：背景:胶原蛋白肽是胶原蛋白发生分子链解体、断裂形成的肽混合物,具有分子质量小、生物相容性好、吸收性好等特性,在生物医药、化妆品、食品等多领域应用广泛。目的:介绍胶原蛋白及胶原蛋白肽的结构特点、分类、来源,重点论述胶原蛋白肽的制备方法和应用,以及透皮吸收评价方法,对从水产动物资源中获取高质量的胶原蛋白肽原料,应用于生物医疗、化妆品等高附加值领域的发展趋势进行展望。方法:用计算机检索PubMed、CNKI、万方数据库中1997年1月至2020年6月有关胶原蛋白肽的制备、检测方法及透皮吸收评价方法的文献,中文以“胶原蛋白,胶原蛋白肽,透皮吸收,胶原肽制备,胶原肽检测”为检索词进行检索,英文以“collagen,collagen peptide,transdermal absorption,preparation of collagen peptide,collagen peptide detection”为检索词进行检索。结果与结论:对于胶原蛋白肽制备的研究已经有很多,且已应用于实际生产中,但对于胶原蛋白肽透皮吸收评价方法的研究很少,主要仍是借鉴药物经皮渗透的研究方法。国内的胶原蛋白肽产业还未成熟,仍存在着一些问题,在产品的研究开发过程中应该充分关注其实际应用效果,注重产品生产精制化、产品功能细致化,提升产品专业度,才能更有利于产业发展。BACKGROUND: Collagen peptide, the peptide mixtures formed by the disassembly and breakage of molecular chains of collagen, is applied widely across domains including biomedicine, cosmetics and food thanks to its characteristics of low molecular weight, excellent biocompatibility, and good absorptivity. OBJECTIVE: To introduce the structural characteristics, classification and sources of collagen and collagen peptides, focus upon the preparation and bioactivity of collagen peptide and the evaluation of transdermal absorption. We prospected the future to obtain quality collagen peptide material from aquatic animal and to apply it to domains with high added value including biomedicine and cosmetics.METHODS: We searched the articles published from January 1997 to June 2020 in PubMed, CNKI, and Wanfang databases about the preparation and examination of collagen peptide and the methods of evaluating transdermal absorption with the keywords including "collagen, collagen peptide, transdermal absorption, preparation of collagen peptide, collagen peptide detection" in Chinese and English respectively.RESULTS AND CONCLUSION: Studies into evaluation methods of the transdermal absorption of collagen peptides remain to be few in numbers, though there has been a lot about the preparation of collagen peptides. The existing studies upon the evaluation methods are majorly based upon those into the transdermal penetration of drugs. In the context where the collagen peptide industry in China remains to be immature, full attention should be paid to the actual effect and the products should be refined with the more specifically classified functions in the progress of product research and development.

关 键 词：材料 胶原蛋白 胶原蛋白肽 分析方法 生物活性 透皮吸收 综述 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学]