叉状头/翅膀状螺旋转录因子3和膜突白在非小细胞肺癌组织的表达及其临床意义  

Expression and clinical significance of forkhead box P3 and membrane-organizing extension spike protein in non-small cell lung cancer tissues

作　　者：梁克 梁卫明 谢锐 王桢玮 杨海霞 陈曼 Liang Ke;Liang Weiming;Xie Rui;Wang Zhenwei;Yang Haixia;Chen Man(Department of Chest Surgery,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China;Department of Interventionan Medicine,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China;The First Clinical Medical College of Guangdong Medical University,Zhanjiang 524001,China;Oncology Center,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China)

机构地区：[1]广东医科大学附属医院胸外科,湛江524001 [2]广东医科大学附属医院介入科,湛江524001 [3]广东医科大学第一临床学院,湛江524001 [4]广东医科大学附属医院肿瘤中心,湛江524001

出　　处：《中华实验外科杂志》2021年第4期734-736,共3页Chinese Journal of Experimental Surgery

基　　金：湛江市科技发展专项资金竞争性分配项目(2017A01011)。

摘　　要：目的探讨叉状头/翅膀状螺旋转录因子3(Foxp3)和膜突蛋白(Moesin)在非小细胞肺癌(NSCLC)组织的表达及临床意义。方法收集广东医科大学附属医院2016年4月至2020年12月病理学确诊的102例NSCLC患者癌组织标本和对应癌旁组织标本,采用免疫组织化学法检测上述组织中Foxp3以及Moesin表达水平,采用χ^(2)检验统计学分析两者与NSCLC临床病理参数的关系。结果NSCLC组织Foxp3蛋白阳性表达率为65.69%(67/102)、对应癌旁组织Foxp3蛋白阳性表达率[22.55%(23/102)],两者差异有统计学意义(χ^(2)=38.494,P<0.01);Foxp3表达水平与NSCLC淋巴结转移、TNM分期(TNM stage)明显相关(χ^(2)=5.890、4.603,P<0.05)。NSCLC组织Moesin蛋白阳性表达率为83.33%(85/102)、对应癌旁组织Moesin蛋白阳性表达率[15.69%(16/102)],两者差异有统计学意义(χ^(2)=93.362,P<0.01);Moesin表达水平与NSCLC组织学分化程度、淋巴结转移、TNM分期明显相关(χ^(2)=8.483、4.910、4.175,P<0.05)。结论Foxp3和Moesin表达上调与NSCLC患者病情密切相关,有助于评估NSCLC发生、侵袭转移和预后。Objective To investigate the expression and clinical significance of forkhead box P3(Foxp3)and membrane-organizing extension spike protein(Moesin)in non-small cell lung cancer(NSCLC).Methods Foxp3 and Moesin expression in 102 cases of human NSCLC tissues and non-cancerous adjacent lung tissues pathologically confirmed from April 2016 to December 2020 on Affiliated Hospital of Guangdong Medical University was examined by using envision immunohistochemistry.The statistical analysis of Chi-square test was carried out in combination with the relationships between the expression of Foxp3 and Moesin and the clinicopathological features of NSCLC.Results Foxp3 expression in NSCLC tissues and the non-cancerous adjacent lung tissues was 65.69%(67/102)and 22.55%(23/102)respectively,and differences were statistically significant(χ^(2)=38.494,P<0.01).The expression of Foxp3 was associated with NSCLC to lymph node metastasis and tumor node metastasis stage(TNM stage)(respectively,χ^(2)=5.890,4.603,P<0.05).Moesin expression in NSCLC tissues and the non-cancerous adjacent lung tissues was 83.33%(85/102)and 15.69%(16/102)respectively,and differences were statistically significant(χ^(2)=93.362,P<0.01).The expression of Moesin was associated with NSCLC to histology grade,TNM stage and lymph node metastasis(respectively,χ^(2)=8.483,4.910,4.175,P<0.05).Conclusion Foxp3 and Moesin up-regulation is closely related to disease status of patients with NSCLC,which may be indicators of the occurrence,invasion,metastasis and prognosis of NSCLC.

关 键 词：非小细胞肺癌 免疫组织化学法 

分 类 号：R734.2[医药卫生—肿瘤]