生长抑素联合盐酸普萘洛尔治疗肝硬化门静脉高压致上消化道出血的疗效观察  

Efficacy observation of somatostatin and propranolol hydrochloride in the treatment of upper gastrointestinal hemorrhage caused by cirrhotic portal hypertension

作　　者：苏文玉[1] SU Wen-yu(Department of Infectious Diseases,Jianping County Hospital,Chaoyang 122400,China)

机构地区：[1]辽宁省朝阳市建平县医院感染科,122400

出　　处：《中国实用医药》2021年第12期15-17,共3页China Practical Medicine

摘　　要：目的观察生长抑素(SST)联合盐酸普萘洛尔治疗肝硬化门静脉高压致上消化道出血的临床效果。方法60例肝硬化门静脉高压致上消化道出血患者,按随机数字表法分为对照组和观察组,各30例。对照组接受生长抑素治疗,观察组在对照组基础上联合盐酸普萘洛尔治疗。对比两组患者治疗前后脾静脉血流量、门静脉血流量,治疗效果,不良反应发生情况。结果治疗后,观察组脾静脉血流量(276.42±45.36)ml/min、门静脉血流量(550.65±51.23)ml/min均显著少于对照组的(313.54±69.84)、(640.36±45.36)m l/min,差异具有统计学意义(P<0.05)。观察组临床治疗总有效率90.00%明显高于对照组的63.33%,差异具有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论对于肝硬化门静脉高压所致上消化道出血患者予以生长抑素与盐酸普萘洛尔联合治疗,可有效提升疗效,尽快改善静脉血流量,且安全性较高,值得进一步推广。Objective To observe the clinical effect of somatostatin(SST)and propranolol hydrochloride in the treatment of upper gastrointestinal hemorrhage caused by cirrhotic portal hypertension.Methods A total of 60 patients with upper gastrointestinal hemorrhage caused by cirrhotic portal hypertension were divided into control group and observation group according to random numerical table,with 30 cases in each group.The control group was treated with somatostatin,and the observation group was treated with propranolol hydrochloride based on the control group.The splenic vein blood flow and portal vein blood flow before and after treatment,therapeutic effect,and occurrence of adverse reactions were compared between the two groups.Results After treatment,the splenic vein blood flow(276.42±45.36)ml/min and portal vein blood flow(550.65±51.23)ml/min of the observation group were significantly less than(313.54±69.84)and(640.36±45.36)ml/min of the control group,and the difference was statistically significant(P<0.05).The total effective rate of clinical treatment 90.00%of the observation group was obviously higher than 63.33%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two group(P>0.05).Conclusion For patients with upper gastrointestinal hemorrhage caused by cirrhotic portal hypertension,combination of somatostatin and propranolol hydrochloride can effectively improve the efficacy,improve the vein blood flow as soon as possible,and has high safety.It is worthy of further promotion.

关 键 词：肝硬化门静脉高压 上消化道出血 生长抑素 盐酸普萘洛尔 

分 类 号：R575.2[医药卫生—消化系统]