MRI对脑萎缩认知正常患者发生阿尔茨海默病的风险预测价值  

The value of MRI in predicting the risk of Alzheimer's disease in brain atrophy patients with normal learning

作　　者：彭小江 卢志伟[2] 莫健超[3] PENG Xiao-jiang;LU Zhi-wei;MO Jian-chao(Zhaoqing Medical College,Zhaoqing 526020,China)

机构地区：[1]肇庆医学高等专科学校,526020 [2]广州医科大学附属脑科医院神经内科,510370 [3]肇庆医学高等专科学校附属医院外科,526020

出　　处：《中国实用医药》2021年第12期70-72,共3页China Practical Medicine

摘　　要：目的探究磁共振成像(MRI)对脑萎缩认知正常(NL)患者发生阿尔茨海默病(AD)的风险预测价值。方法 50例NL患者,所有患者均开展纵向脑MRI检查,根据检查结果将25例脑萎缩NL患者设为观察组,余25例NL患者设为对照组。比较两组AD发病率及感兴趣区域(ROI)厚度。结果观察组AD发病率为40.00%,显著高于对照组的4.00%,差异有统计学意义(P<0.05)。观察组左面内嗅皮层(EC)、眶额皮质(OFC)、后扣带回皮层(PCC)的ROI厚度均小于对照组,差异有统计学意义(P<0.05)。结论脑萎缩NL患者患AD的风险远高于NL患者,并且尤其是右大脑半球发生风险的几率很高,具有显著的OFC、EC和PCC指标。Objective To investigate the value of magnetic resonance imaging(MRI)in predicting the risk of Alzheimer's disease(AD)in brain atrophy patients with normal learning(NL).Methods All 50 NL patients underwent longitudinal brain MRI examination.According to the examination results,25 NL patients with brain atrophy were set as the observation group,and the remaining 25 NL patients were set as the control group.The incidence of AD and thickness of region of interest(ROI)were compared between the two groups.Results The incidence of AD of the observation group was 40.00%,which was significantly higher than 4.00%of the control group,and the difference was statistically significant(P<0.05).The ROI thickness of left entorhinal cortex(EC),orbital frontal cortex(OFC)and posterior cingulate cortex(PCC)of the observation group were less than those of the control group,and the difference was statistically significant(P<0.05).Conclusion The risk of AD in NL patients with brain atrophy is much higher than that in NL patients,and especially a high risk of occurrence in the right hemisphere,accompanied by significant OFC,EC and PCC indicators.

关 键 词：磁共振成像 脑萎缩 认知正常 阿尔茨海默病 

分 类 号：R749.16[医药卫生—神经病学与精神病学]