盐酸吉西他滨联合化疗治疗晚期膀胱癌的临床价值分析  

Analysis of clinical value of gemcitabine hydrochloride in the treatment of advanced bladder cancer

作　　者：李杰 LI Jie(Department of Pharmacy,Liaoyang Fifth People's Hospital,Liaoyang 111000,China)

机构地区：[1]辽宁省辽阳市第五人民医院药剂科,111000

出　　处：《中国实用医药》2021年第12期120-123,共4页China Practical Medicine

摘　　要：目的观察盐酸吉西他滨联合化疗治疗晚期膀胱癌的临床价值。方法 30例晚期膀胱癌患者,采用随机数字表法分为观察组与对照组,每组15例。对照组给予常规+顺铂治疗,观察组在对照组基础上加用盐酸吉西他滨治疗。比较两组患者尿液肿瘤相关因子水平、临床疗效。结果治疗前,两组膀胱肿瘤抗原(BTA)、核基质蛋白(NMP)、尿膀胱癌抗原(UBC)水平比较差异无统计学意义(P>0.05);治疗后,两组患者BTA、NMP、UBC水平均较治疗前降低,观察组明显低于对照组,差异有统计学意义(P<0.05)。观察组总有效率86.7%(13/15)高于对照组的53.3%(8/15),差异具有统计学意义(χ^(2)=3.968,P<0.05)。结论盐酸吉西他滨联合化疗治疗晚期膀胱癌,可以改善患者肿瘤因子,效果可靠,值得临床推广。Objective To observe the clinical value of gemcitabine hydrochloride in the treatment of advanced bladder cancer. Methods A total of 30 patients with advanced bladder cancer were divided into observation group and control group according to random numerical table, with 15 cases in each group. The control group was treated with conventional therapy+ cisplatin, and the observation group was treated with gemcitabine hydrochloride based on the control group. The urine tumor related factors level and clinical efficacy were compared between the two group. Results Before treatment, there was no statistically significant difference in bladder tumor antigen(BTA), nuclear matrix protein(NMP) and urinary bladder cancer antigen(UBC) between the two groups(P>0.05). After treatment, the levels of BTA, NMP and UBC of the two groups were lower than those before treatment, and the observation group was obviously lower than the control group. All the difference was statistically significant(P<0.05). The total effective rate 86.7%(13/15) of the observation group was higher than 53.3%(8/15) of the control group, and the difference was statistically significant(χ^(2)=3.968, P<0.05). Conclusion Hydrochloride combined with chemotherapy shows reliable effect in the treatment of advanced bladder cancer, and it can significantly improve the tumor factors. It is worthy of clinical promotion.

关 键 词：盐酸吉西他滨 晚期膀胱癌 化疗 顺铂 肿瘤因子 

分 类 号：R737.14[医药卫生—肿瘤]