薄芝糖肽注射液联合呲柔比星治疗乳腺癌的效果研究  

Effect of Bozhi glycopeptide injection combined with Pirarubicin in the treatment of breast cancer

作　　者：李巍[1] 李海洲[1] 焦立新[1] 李向东[1] 何玉男 王嵬[1] LI Wei;LI Hai-zhou;JIAO Li-xin(Jinzhou Central Hospital,Jinzhou 121000,China)

机构地区：[1]锦州市中心医院,121000

出　　处：《中国实用医药》2021年第12期126-128,共3页China Practical Medicine

摘　　要：目的研究薄芝糖肽注射液联合呲柔比星治疗乳腺癌的效果。方法40例乳腺癌患者,通过双色球法随机分为对照组和观察组,每组20例。对照组患者进行常规化疗,观察组患者在对照组基础上加用薄芝糖肽注射液治疗。比较两组患者卡氏量表(KPS)评分、毒副反应发生情况及治疗效果。结果观察组患者的KPS评分为(89.16±3.59)分,明显高于对照组的(81.64±4.33)分,差异具有统计学意义(t=5.979,P=0.000<0.05)。两组患者肝脏毒性发生情况比较差异无统计学意义(P>0.05);观察组的胃肠道毒性、骨髓毒性严重程度明显低于对照组,差异具有统计学意义(P<0.05)。观察组的治疗总有效率80%高于对照组的50%,差异具有统计学意义(χ^(2)=3.956,P=0.047<0.05)。结论在传统呲柔比星等药物化疗基础上应用薄芝糖肽注射液治疗乳腺癌,可有效改善治疗效果,提高患者生活质量,同时还能减轻毒副反应,基本不会对肝脏产生损伤,值得临床推广。Objective To study the effect of Bozhi glycopetide injection combined with Pirarubicin in the treatment of breast cancer. Methods A total of 40 patients with breast cancer were divided into control group and observation group according to two-color ball method, with 20 cases in each group. The control group was treated with conventional chemotherapy, and the observation group was treated with Bozhi glycopeptide injection based on the control group. The Karnofsky performance scale(KPS) score, occurrence of side effects and therapeutic effect were compared between the two groups. Results The KPS score of the observation group was(89.16± 3.59) points, which was obviously higher than(81.64±4.33) points of the control group, and the difference was statistically significant(t=5.979, P=0.000<0.05). There was no statistically significant difference in incidence of hepatotoxicity between the two groups(P>0.05). The gastrointestinal toxicity and severity of bone marrow toxicity of the observation group were obviously lower than those of the control group, and the difference was statistically significant(P<0.05). The total effective rate 80% of the observation group was higher than 50% of the control group, and the difference was statistically significant(χ^(2)=3.956, P=0.047<0.05). Conclusion In the treatment of breast cancer, application of Bozhi glycopeptide injection on the basis of traditional Pirarubicin chemotherapy can effectively improve the therapeutic effect and the quality of life of the patients, and at the same time reduce the side effects, basically will not cause damage to the liver, which is worthy of clinical promotion.

关 键 词：薄芝糖肽注射液 呲柔比星 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]