自噬调控T淋巴细胞功能在疾病发生发展中作用的研究进展  

Research progress on roles of autophagy regulating T lymphocyte function in the genesis and development of diseases

作　　者：杨艺 刘沁颖[2] 郑秋红[2] 陈立 YANG Yi;LIU Qinying;ZHENG Qiuhong;CHEN Li(Institute of Biomedical and Pharmaceutical Technology,Fuzhou University,Fuzhou 350002,Fujian,China;Fujian Provincial Key Laboratory of Tumor Biotherapy,Fujian Provincial Cancer Hospital&Cancer Hospital Affiliated to Fujian Medical University,Fuzhou 350014,Fujian,China)

机构地区：[1]福州大学生物和医药技术研究院,福建福州350002 [2]福建省肿瘤医院&福建医科大学附属肿瘤医院,福建省肿瘤生物治疗重点实验室,福建福州350014

出　　处：《中国肿瘤生物治疗杂志》2021年第3期215-224,共10页Chinese Journal of Cancer Biotherapy

基　　金：福建省社会发展引导性重点项目资助(No.2018Y0015);福州大学贵重仪器设备开放测试基金资助项目(No.2020T022)。

摘　　要：自噬作为一种重要的胞内代谢途径,已被证实普遍存在于多种细胞中,其功能的异常易引发癌症、肝病、糖尿病和心脏病等疾病。自噬在T淋巴细胞自身发育分化及调节T淋巴细胞免疫功能方面也扮演着重要角色,T淋巴细胞自噬异常会造成其免疫功能紊乱进而引发炎症、感染和自身免疫性等疾病。鉴于自噬在调控T淋巴细胞功能和疾病发生发展中的重要作用,本文重点阐述自噬调控T淋巴细胞稳态、存活、增殖、衰老、代谢、免疫功能,以及在包括肿瘤在内的多种疾病发生发展中作用的研究进展。Autophagy, as an important intracellular metabolic pathway, has been proved to be ubiquitous in many kinds of cells. Its functional impairment can easily cause lots of diseases, such as cancer, leukemia, liver disease, diabetes and heart disease. In particular,autophagy is important for the development, differentiation and regulation of immune function of T lymphocytes. Abnormal autophagy of T lymphocytes can cause immune dysfunction and lead to diseases, such as inflammation, infection and autoimmunity. In view of the important role of autophagy in regulating T lymphocyte function and disease, this article illustrates the research progress on autophagy regulating the homeostasis, survival, proliferation, senescence, metabolism, immune function of T lymphocytes and many diseases,including tumors, in recent years.

关 键 词：T淋巴细胞功能 自噬 免疫 抗肿瘤 疾病 

分 类 号：R730.3[医药卫生—肿瘤] R392.12[医药卫生—临床医学]