The advantage of low-dose clomiphene citrate for overweight women with anovulation  

作　　者：Ping-Ping Sun Na Sun Yue-Min Zhang Jin-Guang Wang Hua-Gang Ma 

机构地区：[1]The Reproductive Medicine Centre of Weifang People's Hospital,Weifang 261041,Shandong,China.

出　　处：《Drug Combination Therapy》2021年第2期29-34,共6页药物联合治疗

摘　　要：Background:To investigate the potential advantage of using low-dose clomiphene citrate to promote ovulation in women with overweight or obesity.Methods:The patients with overweight were divided randomly into regular clomiphene citrate group(clomiphene citrate 50 mg/d,n=83)and low-dose clomiphene citrate group(clomiphene citrate 25 mg/d,n=105).All patients received treatment from the 5th day of their menstrual cycles.Results:Luteinizing hormone levels and estradiol levels were more increased in the low-dose group compared with the regular group(P<0.05).Low-dose group showed significantly thicker endometrium,fewer dosage and shorter days of human menopausal gonadotropin,less numbers of mature follicles and lower rates of cancellation(P<0.05)on human chorionic gonadotropin day.After human chorionic gonadotropin injection,the ovulation rate in the low-dose group was significantly higher than the regular group(P<0.05).No difference was detected in the biochemical pregnancy rates both groups(P>0.05).Conclusion:The low-dose clomiphene citrate treatment significantly reduced the number of mature follicles and increased the thickness of endometrium on the human chorionic gonadotropin day with less side effects.The low-dose clomiphene citrate also achieved the better ovulation rate.

关 键 词：Clomiphene citrate Ovulation promotion OVERWEIGHT Obesity Multiple follicle Endometrium thickness 

分 类 号：R73[医药卫生—肿瘤]