广西中老年女性宫颈人乳头瘤状病毒感染流行病学研究  

An Epidemiological Study of Infection of Cervical Human Papilloma Virus Among Middle-aged and Elderly Female in Guangxi Province

作　　者：李兴华 韦晓宁 张思辰[2] 王少为 LI Xinghua;WEI Xiaoning;ZHANG Sichen;WANG Shaowei(Graduate School of Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730;National geriatric center of Obstetrics and Gynecology,Beijing hospital,Institute of Geriatrics,Chinese Academy of Medical Sciences,Beijing 100730;Obstetrics and Gynecology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021;Department of Obstetrics and Gynecology,the first hospital of Fangshan District,Beijing 102400, China)

机构地区：[1]中国医学科学院北京协和医学院研究生院,100730 [2]北京医院妇产科,国家老年医学中心,中国医学科学院老年医学研究院,100730 [3]广西医科大学第一附属医院妇产科,530021 [4]北京房山区第一医院妇产科,102400

出　　处：《中国老年保健医学》2021年第2期33-37,共5页Chinese Journal of Geriatric Care

摘　　要：目的调查分析广西中老年女性宫颈人乳头状病毒(Human Papilloma Virus,HPV)感染的流行病学特征,为中老年女性HPV感染的防治提供理论依据。方法回顾性分析2018年1月至2020年12月在广西医科大学第一附属医院妇产科门诊及住院的中老年患者的民族信息以及HPV分型的检查结果。将入组患者分为汉族组、壮族组及其他民族组三个组别。应用聚合酶联反应(Polymerase Chain Reaction,PCR)技术进行HPV分型检测,分析广西中老年女性宫颈HPV的流行病学特征。结果广西中老年壮族与汉族女性HPV、HR-HPV感染率无明显差异;壮族组HR-HPV感染率除65~69岁年龄段低于汉族组外,其余年龄段均高于汉族组。汉族人群与壮族人群感染率高峰均出现在70~74岁以及75~79岁年龄组,汉族组HR-HPV感染率分别为37.50%和33.33%,壮族组此两年龄段HR-HPV感染率则与总HPV感染率相同。LR-HPV感染率汉族组与壮族组水平相似,仅在65~69岁年龄组中现差异,壮族组LR-HPV感染率高于汉族组(13.21%vs 6.14%),并无统计学差异。汉族与壮族中老年女性HPV感染率高峰位于70~79岁之间,80岁以后下降;该地区汉族女性阳性率最高的HR-HPV分型为HPV 16、HPV 52、HPV 58、HPV 39及HPV 51,壮族女性中则为HPV 16、HPV 52、HPV 58、HPV 39及HPV 33;汉族与壮族人群LR-HPV感染率最高的两种亚型为HPV 53及CP8304。结论广西中老年壮族与汉族女性HPV、HR-HPV感染率无明显差异,感染高峰年龄为70~79岁。该地区汉族女性阳性率最高的HR-HPV分型为HPV 16、HPV 52、HPV 58、HPV 39及HPV 51,壮族女性为HPV 16、HPV 52、HPV 58、HPV 39及HPV 33;汉族与壮族人群LR-HPV感染率最高的两种亚型为HPV 53及CP8304。Objective To provide the basis of theories for preventing and treating Human Papilloma Virus(HPV)in middle-aged and elderly female in Guangxi Province,this study aimed to survey and analysis of epidemiological characteristics of infection of HPV of them.Methods This is a retrospective study.The baseline population information and results of HPV of middle-aged and elderly patients were collected from the out-patient and in-patient department of gynecology of the First Affiliated Hospital of Guangxi Medical University during January 2018 and December 2020.This study was divided into three groups depending on the nationality:Han group,Zhuang group,and other ethnic groups.Polymerase Chain Reaction(PCR)was used for HPV genotyping detection,and the epidemiological characteristics of HPV of middle-aged and elderly female in Guangxi were analyzed.Results There was no significant difference of HPV and HR-HPV positive rates between middle-aged and elderly Zhuang and Han women in Guangxi province.The HR-HPV positive rate in Zhuang group was higher than that in Han group except the group of 55~69 years old.The top positive rates of HR-HPV in both Han and Zhuang groups showed in the group of 70~74 years old and 75~79 years old.The HR-HPV positive rates in the Han group were 37.50%and 33.33%,meanwhile,the HR-HPV positive rate in the Zhuang group was consistent with the total HPV positive rate in the two groups.LR-HPV positive rate in Han group was similar with that of Zhuang group,also the difference was only found in the group of 65~69 years old.LR-HPV positive rate of Zhuang group was higher than that of Han group(13.21%vs 6.14%).HPV highest positive rates of Han and Zhuang middle-aged and elderly women were 70~79 years old,but it decreased after 80 years old.The most common subtypes of HR-HPV were HPV 16,HPV 52,HPV 58,HPV 39 and HPV 51 in Han women,and HPV 16,HPV 52,HPV 58,HPV 39 and HPV 33 in Zhuang women.And the two highest frequent subtypes of LR-HPV in Han and Zhuang populations were HPV 53 and CP8304.Conclusion There i

关 键 词：人乳头状病毒 中老年 女性 流行病学 

分 类 号：R73[医药卫生—肿瘤]