临床药师干预前后消化内科抗菌药物使用情况比较  

Comparison of the Usage of Antibiotics in the Department of Gastroenterology Before and After Intervention by Clinical Pharmacists

作　　者：朱永红[1] 陈伯华[1] 殷晓芹[1] 罗佳[1] 王爽[1] ZHU Yonghong;CHEN Bohua;YIN Xiaoqin;LUO Jia;WANG Shuang(Department of Pharmacy,Affiliated Hospital of Nantong University,Nantong,Jiangsu,China 226001)

机构地区：[1]南通大学附属医院药学部,江苏南通226001

出　　处：《中国药业》2021年第9期92-96,共5页China Pharmaceuticals

基　　金：江苏省南通市药物政策科研项目[YAOZ201908];江苏省南通市卫生健康委员会科研项目[MB2019052]。

摘　　要：目的比较临床药师干预前后消化内科抗菌药物的使用情况,为临床合理使用抗菌药物提供参考。方法选取医院消化内科2018年10月至12月(干预前,309例)和2019年3月至5月(干预后,243例)使用抗菌药物的患者,比较临床药师干预前后使用抗菌药物疾病分布变化、抗菌药物使用情况及抗菌药物合理使用情况。结果干预前后使用抗菌药物排名前5位的疾病有胆道系统感染、急性胰腺炎、消化道出血、胃肠息肉及消化道恶性肿瘤;干预后,抗菌药物使用强度均在2019年度目标管控值(77.38)以下;各类抗菌药物的用量和费用均下降,拉氧头孢用量最大,奥硝唑和左氧氟沙星用量均大幅下降;抗菌药物不合理用药和联合用药例数均降低,用药时长缩短;限制使用级抗菌药物微生物送检率为18.11%,特殊使用级抗菌药物微生物送检率为82.61%。结论临床药师干预消化内科抗菌药物使用,可提高合理使用水平,降低抗菌药物使用量,但不合理使用情况仍有待改进。Objective To compare the usage of antibiotics in the Department of Gastroenterology before and after the intervention by clinical pharmacists,and to provide a reference for clinical rational use of antibiotics.Methods The patients who used antibiotics in the Department of Gastroenterology in our hospital from October to December 2018(309 cases,before intervention)and from March to May 2019(243 cases,after intervention)were selected to compare the changes in the distribution of disease using antibiotics,use of antibiotics and rational use of antibiotics before and after intervention by clinical pharmacists.Results Before and after the intervention,the top five diseases using antibiotics were biliary tract infection,acute pancreatitis,gastrointestinal bleeding,gastrointestinal polyps and gastrointestinal malignancies.After the intervention,the use intensity of antibiotics was within the target-controlled value of 2019(77.38),the usage amount and cost of all kinds of antibiotics decreased,of which the usage amount of latamoxef was the largest,while the usage amount of ornidazole and levofloxacin decreased significantly,the number and time of irrational and combined use of antibiotics were reduced,and the duration of drug use was shortened,and the microbial detection rate of restricted-use antibiotics was18.11%,and that of special use antibiotics was 82.61%.Conclusion Clinical pharmacists’intervention in the use of antibiotics in the Department of Gastroenterology can improve rational drug use and reduce the usage of antibiotics,but irrational use still needs to be improved.

关 键 词：临床药师 消化内科 抗菌药物 干预 使用情况 

分 类 号：R95[医药卫生—药学] R978.1