The potential of ionic liquids in biopharmaceutical engineering  

作　　者：Xuan Lin Zhiguo Su Yanli Yang Songping Zhang 

机构地区：[1]State Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China

出　　处：《Chinese Journal of Chemical Engineering》2021年第2期236-243,共8页中国化学工程学报（英文版）

基　　金：The authors are thankful for the financial support from the National Natural Science Foundation of China(Nos.21808226,31970872,and 21821005).

摘　　要：Biopharmaceuticals,such as proteins,peptides,nucleic acids and vaccines,bring about great hopes for the prevention and treatment of various diseases,but the industrialization of these products still faces challenges such as structural instability,inefficient bioactivity and low bioavailability.Ionic liquids(ILs),the marvelous solvent media with inimitable and tunable properties,may provide alternative solutions to overcome the above problems of biopharmaceutical industry.Progress has gradually been made through studies by combination of ILs with biomacromolecules.The applications involved the stabilization,protection,and delivery of biopharmaceuticals.Recent trends are being forwarded to using ILs in vaccines and nucleic acid drugs.However,challenges remain on the toxicity and safety issues.Besides,the cost of adding ILs to the benefits of biopharmaceuticals need to be considered.

关 键 词：Ionic liquids Biopharmaceutical engineering BIOMACROMOLECULES STABILIZATION VACCINE Delivery 

分 类 号：TQ460.1[化学工程—制药化工] TQ413.2