揉眼在圆锥角膜发生和发展中的作用  

Role of eye rubbing in the occurrence and development of keratoconus

作　　者：李丹(综述)[1] 任胜卫 赵东卿(审校)[2] Li Dan;Ren Shengwei;Zhao Dongqing(Xinxiang Medical University,Xinxiang 453003;Henan Provincial People's Hospital,Henan Eye Hospital,Zhengzhou 450003,China)

机构地区：[1]新乡医学院,453003 [2]河南省人民医院河南省立眼科医院,郑州450003

出　　处：《中华实验眼科杂志》2021年第4期356-359,共4页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金青年基金项目(81200664);河南省自然科学基金项目(182300410362);河南省基础与前沿技术研究计划项目(162300410235)。

摘　　要：圆锥角膜是一种进行性、双侧性角膜疾病,以角膜扩张、中央变薄向前突出呈锥形为特征。圆锥角膜常造成近视和不规则散光,晚期出现的角膜水肿和瘢痕则导致视力显著下降,给患者带来心理压力和经济负担。揉眼是圆锥角膜的一项重要危险因素,许多研究提示揉眼与圆锥角膜的发生和发展有关。不同的揉眼频率和力度会对角膜造成不同影响。在易感人群中,揉眼对角膜造成的伤害更大,后果也更严重。揉眼通过直接机械作用、升高角膜温度和眼压、释放炎性因子导致细胞凋亡等方式损伤角膜。避免揉眼对延缓圆锥角膜的发展有很大作用,通过治疗引起揉眼的原发病和分散注意力等方法减少圆锥角膜患者揉眼的时间和频率,可以减少圆锥角膜的发生或延缓其进展速度,提高患者生活质量。本文对揉眼在圆锥角膜发生和发展中的作用进行综述,为圆锥角膜的防治提供参考。Keratoconus is a progressive and bilateral corneal disease with the characteristics of the protrusion of the dilated and central thinning cornea.Keratoconus often causes myopia and irregular astigmatism,and corneal edema and scarring in the late stage,leads to significant vision loss,and brings patients psychological pressure and economic burden.Eye rubbing is an important risk factor of keratoconus.Many studies suggest that eye rubbing is related to the occurrence and development of keratoconus.Different frequency and intensity of eye rubbing have different effects on the cornea.In susceptible population,eye rubbing causes severer damage to the cornea and more serious consequences.Eye rubbing damages the cornea by direct mechanical action,raising corneal temperature and intraocular pressure and releasing inflammatory factors resulting in cell apoptosis.Avoiding eye rubbing is of great significance in delaying the development of keratoconus.Reducing the rubbing time and frequency of patients with keratoconus by treating the primary disease causing eye rubbing and distracting them can reduce the occurrence and slow down the progression of keratoconus,and the life quality of patients can be improved.In this review,the role of eye rubbing in the etiology of keratoconus was elucidated to provide reference for the treatment and prevention of keratoconus.

关 键 词：圆锥角膜 揉眼 相关性 

分 类 号：R772.2[医药卫生—眼科]