孕激素受体基因多态性与复发性流产易感性关系  

Association of the gene polymorphisms of progesterone receptor of women with their susceptibility of recurrent miscarriage

作　　者：徐玮 蒋盈盈 XU Wei;JIANG Yingying(Taizhou Central Hospital (Affiliated Hospital of Taizhou University), Zhejiang Province, 318000)

机构地区：[1]浙江省台州市中心医院(台州学院附属医院),318000

出　　处：《中国计划生育学杂志》2021年第2期243-245,250,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨孕激素受体(PGR)基因多态性与复发性流产易感性的相关性。方法:选取2016年1月30日—2019年5月30日本院收治的复发性流产孕妇110例(流产组),同期常规产前检查正常妊娠女性110例为正常组,检测两组PGR基因rs590688、rs1942836单核甘酸多态性,并分析其与复发性流产的相关性。结果:流产组rs590688、rs1942836 CC、rs1942836 TC基因型频率均高于正常组,rs1942836 TT基因型频率低于正常组,rs590688及rs1942836 C等位基因频率均高于正常组(均P<0.05)。rs590688 CC基因型(OR=2.05,P<0.05)、rs1942836 TC基因型以及CC基因型者(OR=1.35、2.88,P<0.05)发生复发性流产风险增加。结论:PGR基因rs590688、rs1942836位点多态性与复发性流产易感性显著相关,CC基因型发生复发性流产风险增加。Objective:To investigate association of the gene polymorphism of progesterone receptor(PGR)of women with their susceptibility of recurrent miscarriage.Methods:110 pregnant women with recurrent miscarriage were enrolled in group A from January 30,2016 to May 30,2019,and 110 normal pregnant women were selected in group B during the same period.The polymorphisms of gene rs590688 and rs1942836 of PGR of these women were detected,and their correlation with recurrent abortion of women was analyzed.Results:The genotype frequencies of gene rs590688,gene rs1942836 CC and gene rs1942836 TC,and the allele frequencies of gene rs590688 and gene rs1942836 C of women in group A were significant higher than those of women in group B,but the genotype frequency of gene rs1942836 TT of women in group A was significant lower(all P<0.05).The risk of recurrent abortion of women with genotype rs590688 CC(OR=2.05,P<0.05),and with genotype rs1942836 TC and CC(OR=1.35,2.88,P<0.05)had increased significantly.Conclusion:The polymorphisms of gene rs590688 and rs1942836 of PGR of women are significantly associated with their susceptibility of recurrent miscarriage,and the women with genotype CC has an increased risk of recurrent miscarriage.

关 键 词：复发性流产 孕激素受体 基因多态性 单核甘酸多态性 易感性 

分 类 号：R73[医药卫生—肿瘤]