西医联合活血化瘀治疗子宫肌瘤效果及对患者血清ER、Bcl-2蛋白影响  

Effect of western medicine combined with traditional Chinese medicine about promoting blood circulation and removing blood stasis for treating women with of uterine myoma and its influence on their serum ER and Bcl-2 protein levels

作　　者：蒋艳[1] 黄文英[1] 赵佩汝 杜静[1] JIANG Yan;HUANG Wenying;ZHAO Peiru;DU Jing(Tengzhou Maternal and Child Health Care Hospital,Shandong Province, 277599)

机构地区：[1]山东省滕州市妇幼保健院,277599

出　　处：《中国计划生育学杂志》2021年第2期258-261,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨西医联合中医活血化瘀法对子宫肌瘤疗效及对患者雌激素受体(ER)和Bcl-2蛋白影响。方法:选取2017年10月—2019年3月本院收治的子宫肌瘤患者100例分为西医组和中西医组各50例。西医组给予常规米非司酮治疗,中西医组在西医组西医治疗基础上加用中医活血化瘀法治疗,比较两组临床疗效。结果:治疗后中西医组白细胞介素-2(IL-2)水平高于西医组,ER、Bcl-2水平低于西医组,子宫动脉阻力指数(0.9±0.2)高于西医组,收缩期峰值速度(25.0±5.2 cm/s)、舒张期最小血流速度(5.5±0.9cm/s)低于西医组,总有效率(94.0%)高于西医组(80.0%),生活质量评分(89.1±7.9分)高于西医组(77.2±7.0分)(均P<0.05)。结论:在西医基础上加以中医活血化瘀法可更好地调节子宫肌瘤患者ER、Bcl-2、IL-2的表达水平,减慢子宫血液循环,提高生活质量。Objective:To study the curative effect of western medicine combined with traditional Chinese medicine(TCM)about promoting blood circulation and removing blood stasis for treating women with of uterine myoma,and to study the influence on their levels of estrogen receptor(ER)and Bcl-2 protein.Methods:100 women with uterine myoma were divided into two groups(50 cases in each group)from October 2017 to March 2019.The women in the control group were treated with conventional western medicine,and the women in the study group were treated with western medicine combined with TCM about promoting blood circulation and removing blood stasis.The clinical efficacy of the women was compared between the two groups.Results:After treatment,the level of interleukin-2(IL-2)of the women in the study group was significant higher than that of the women in the control group,but the levels of ER and Bcl-2 of the women in the study group were significant lower.The uterine artery resistance index(0.9±0.2)of the women in the study group was significant higher than that of women in the control group,but the peak systolic velocity value(25.0±5.2 cm/s)and the minimum diastolic flow velocity value(5.5±0.9cm/s)of the women in the study group were significant lower.The total effective rate(94.0%)and the quality of life score(89.1±7.9 points)of the women in the study group were significant higher than those(80.0%and 77.2±7.0 points)of the women in the control group(all P<0.05).Conclusion:Western medicine combined with traditional Chinese medicine about promoting blood circulation and removing blood stasis for treating women with uterine myoma can regulate the expression of ER,Bcl2 and IL2,can reduce the blood circulation of their uterus,and can improve their quality of life.

关 键 词：子宫肌瘤 活血化瘀 雌激素受体 BCL-2蛋白 中西医结合 

分 类 号：R73[医药卫生—肿瘤]