鼠妇提取物对炎性渗出的抑制作用研究  

Evaluation of Inhibitory Activity of Armadillidium Vulgare Latreille on Inflammatory Exudation

作　　者：郭珅珅 许良葵[1] 董健[1] 魏金津 Guo Shenshen;Xu Liangkui;Dong Jian;Wei Jinjin(Guangdong Food and Drug Vocational College,Guangzhou 510520,China)

机构地区：[1]广东食品药品职业学院,广东广州510520

出　　处：《广东化工》2021年第8期119-121,共3页Guangdong Chemical Industry

基　　金：广东省中医药局科研项目(20192062);广东省医学科学技术研究基金(A2020501);广东食品药品职业学院课题(2019ZR07);广东省普通高校特色创新项目(2020KTSCX258)。

摘　　要：本研究主要采用小鼠足肿胀模型,选用角叉菜胶、硫酸葡聚糖和化合物48/80等三种致炎剂开展抗炎实验,考察药材鼠妇对炎性渗出的抑制作用,并采用液质联用技术探索其活性成分。实验结果发现鼠妇提取物能够显著缓解不同炎症模型的炎性水肿程度,表明其具有抑制急性炎性渗出的作用。液相分析表明鼠妇中含有抗炎成分牛磺酸。Phlogogen-induced paw edema test using carrageenan, dextran, or compound 48/80 was performed to evaluate the bioactive effects of the extract of Armadillidium vulgare Latreille on imflammatory exudation. The bioactive compounds of the extract were analysed by HPLC. Oral administration of aqueous extract of these medicine significantly reduced the paw edema volume at 0.6 g/kg and 0.8 g/kg(P<0.05) during the phlogogen-induced edema tests. Taurine was detected and identified in the extract using HPLC. This study indicated the aqueous extract possess inhibitory activity on inflammatory exudation mediated by mast cell degranulation, providing further evidence of its anti-inflammatory activity. Taurine participate in the anti-inflammatory effects of these traditional medicine.

关 键 词：鼠妇水提物 肥大细胞 炎性水肿 牛磺酸 

分 类 号：R285.5[医药卫生—中药学]