Occupational Radiation Exposure and Changes in Thyroid Hormones in a Cohort of Chinese Medical Radiation Workers  

作　　者：GUO Qi Shan RUAN Ping HUANG Wei Xu HUANG Dai Zheng QIU Jia Chu 

机构地区：[1]School of Public Health,Guangdong Pharmaceutical University,Guangzhou 510310,Guangdong,China [2]Guangdong Province Engineering&Technology Research Center for Medical 3D Printer and Personalized Medicine,Guangzhou 510006,Guangdong,China [3]Department of Biomedical Engineering,Guangdong Pharmaceutical University,Guangzhou 510006,Guangdong,China [4]Guangdong Prevention and Treatment Center for Occupational Disease,Guangzhou 510300,Guangdong,China [5]Department of Biomedical Engineering,Guangxi Medical University,Nanning 530021,Guangxi,China

出　　处：《Biomedical and Environmental Sciences》2021年第4期282-289,共8页生物医学与环境科学（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China[81860604];Guangdong Science and Technology Program[2016A020215162];Innovating Strong School Project of Guangdong Pharmaceutical University[51359046]。

摘　　要：Objective This study aimed to evaluate the association between occupational radiation exposure and changes in thyroid hormone levels among medical radiation workers.Methods This retrospective cohort study included 2,946 radiation workers from 20 Guangzhou hospitals.Data on general characteristics,participant radiation dosimetry,and thyroid function test results[thyroid-stimulating hormone(TSH),triiodothyronine(T3),and thyroid hormone(T4)]were extracted from dosimetry and medical records.The generalized estimating equation was used to evaluate the trend of changes in thyroid hormone levels over time and was adjusted for age,gender,and occupation.Results The average annual effective dose was very low and showed a general downward trend.During the follow-up period,changes in T3 and T4 levels among radiation workers were-0.015[95% confidence interval(CI)-0.018 to-0.012]nmol/L per year and-2.294(95%CI-2.426 to-2.162)nmol/L per year,respectively.Thyroid hormone levels were significantly different between males and females.T3 levels in the group of upper quartile of dose were significantly higher than in the lower quartile group(P=0.006).No significant decreased trend in thyroid hormone levels was observed with increasing average effective doses.Conclusion Thyroid hormone secretion might be affected even in low-dose radiation exposure environments.

关 键 词：Occupational radiation Thyroid function COHORT 

分 类 号：R144.1[医药卫生—公共卫生与预防医学]