止痛益气汤联合腹腔化疗治疗HBeAg阳性肝癌疗效及对患者肝功能的影响  

Clinical effect of Zhitong Yiqi decoction combined with peritoneal chemotherapy on HBeAg positive hepatocellular carcinoma and its effect on liver function

作　　者：胡志强 王先正 姜艳红 HU Zhiqiang;WANG Xianzheng;JIANG Yanhong(Chinese Medicine Department,Hainan Cancer Hospital,Haikou 570311,China)

机构地区：[1]海南省肿瘤医院中医科,海南海口570311 [2]郑州大学附属肿瘤医院检验科,河南郑州450008

出　　处：《陕西中医》2021年第5期573-576,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：河南省医学科技攻关项目(201503192)。

摘　　要：目的:探讨止痛益气汤联合腹腔化疗治疗HBeAg阳性肝癌的临床疗效及对患者肝功能的影响。方法:将96例HBeAg阳性患者随机分为对照组与观察组。对照组仅给予腹腔化疗治疗,观察组联合止痛益气汤治疗。比较两组患者治疗前后中医症候积分、外周血T淋巴细胞亚群水平及肝功能水平。结果:观察组治疗后中医症候积分均显著大于对照组(均P<0.05);观察组治疗后CD_(3)^(+)、CD_(4)^(+)及CD_(4)^(+)/CD_(8)^(+)水平均显著高于治疗前及对照组治疗后(均P<0.05),观察组治疗后CD_(8)^(+)水平显著低于治疗前及对照组治疗后(均P<0.05);观察组患者治疗后肝功能相关指标(ALT、AST及TBIL)水平均显著低于对照组(均P<0.05);观察组治疗效果显著优于对照组(P<0.05)。结论:止痛益气汤联合腹腔化疗治疗HBeAg阳性肝癌的疗效显著,可改善患者外周血淋巴细胞亚群水平及肝功能水平。Objective:Investigate the clinical effect of Zhitong Yiqi decoction combined with peritoneal chemotherapy on HBeAg positive liver cancer and its effect on liver function.Methods:A total of 96 HBeAg-positive patients were randomly divided into control group and observation group.The control group was treated with intraperitoneal chemotherapy only,while the observation group was treated with Zhitong Yiqi decoction.The scores of TCM syndromes,T lymphocyte subsets in peripheral blood and liver function of the two groups were compared before and after treatment.Results:The scores of TCM syndromes the post-treatment in the observation were significantly lower than the scores of the post-treatment in the control(all P<0.05).After treatment,the levels of CD 3^(+),CD 4(+)and CD4(+)/CD 8(+)of the observation group were significantly higher than before and after treatment of the control group(all P<0.05),and the CD 8(+)was on the contrary between the two groups(P<0.05).After treatment,the levels of liver function related indicators(ALT,AST and TBIL)of the observation group were significantly lower than the control group(all P<0.05).The treatment effect of the observation group was better than the control group(P<0.05).Conclusion:Zhitong Yiqi decoction combined with peritoneal chemotherapy has a significant effect on HBeAg positive liver cancer,and can improve the level of peripheral blood lymphocyte subsets and liver function in patients,which should be promoted and applied.

关 键 词：HBeAg阳性肝癌 止痛益气汤 腹腔化疗 外周血淋巴细胞亚群 肝功能 

分 类 号：R735.7[医药卫生—肿瘤]