B7-H4在肝内胆管癌的表达及临床意义  

Expression of B7-H4 in Intrahepatic Cholangiocarcinoma and Its Clinical Significance

作　　者：李刚 李金凇 谢楠[2] 李春满[2] 魏雷[2] 曹凡 苏莹珍[3] LI Gang;LI Jin-song;XIE Nan;LI Chun-mang;WEI Lei;CAO Fan;SU Ying-zhen(Dept.of Hepatobiliary Surgery,Cancer Hospital of Chengdu Medical College,The Seventh People’s Hospital of Chengdu,Chengdu Sichuan 610000;The 4th Area,Dept.of Hepatobiliary and Pancreas Surgery,The Second Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650101;Dept.of Laboratory Science and Preventive Medicine,Kunming University,Kunming Yunnan 650214,China)

机构地区：[1]成都市第七人民医院/成都医学院附属肿瘤医院肝胆外科,四川成都610000 [2]昆明医科大学第二附属医院肝胆胰外科四病区,云南昆明650101 [3]昆明学院检验学和预防医学教研室,云南昆明650214

出　　处：《昆明医科大学学报》2021年第4期78-83,共6页Journal of Kunming Medical University

基　　金：云南省科技厅-地方高校联合专项基金资助项目(201901O070206);云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(202001AY070001-213);云南省教育厅科学研究基金资助项目(2019J0567)。

摘　　要：目的探讨协同共刺激分子B7-H4在肝内胆管癌组织中的表达及其临床意义。方法采用免疫组化检测90例肝内胆管癌(intrahepatic cholangiocarcinoma,ICC)及其癌旁组织中B7-H4的表达,并分析B7-H4表达与患者临床病理特征及预后关系。结果在肝内胆管癌中B7-H4表达率为44.4%,明显高于癌旁组织,且肝内胆管癌中B7-H4表达上升与TNM分期、肿瘤的分化、淋巴结转移及不良预后相关(P<0.05)。生存分析提示B7-H4高表达组患者术后总生存率明显低于B7-H4低表达组(P=0.005)。Cox比例风险回归模型分析表明B7-H4是肝内胆管癌患者的独立预后因子。结论B7-H4在肝内胆管癌组织中表达增加,且B7-H4高表达与ICC患者恶性病理特征及不良预后密切相关,对预估患者预后有一定临床指导意义。Objective To investigate the expression of costimulatory molecule B7-H4 in intrahepatic cholangiocarcinoma(ICC)and its clinical significance.Methods Immunohistochemistry was used to detect the expression of B7-H4 in 90 cases of intrahepatic cholangiocarcinoma and its adjacent tissues,and analyzed the correlation between B7-H4 expression and the clinicopathological characteristics and prognosis of the patients.Results The expression rate of B7-H4 in intrahepatic cholangiocarcinoma was 44.4%,which was significantly higher than that of adjacent tissues.The increased expression of B7-H4 in intrahepatic cholangiocarcinoma was related to TNM staging,tumor differentiation,lymph node metastasis and poor prognosis(P<0.05).Survival analysis revealed that the overall survival rate of patients in the B7-H4 high expression group was significantly lower than that in the B7-H4 low expression group(P=0.005).Cox proportional hazards regression model analysis showed that B7-H4 is an independent prognostic factor for patients with intrahepatic cholangiocarcinoma.Conclusion The expression of B7-H4 is increased in intrahepatic cholangiocarcinoma tissues,and the high expression of B7-H4 is closely related to the malignant pathological characteristics and poor prognosis of ICC patients,which has clinical guiding significance for predicting the prognosis of patients.

关 键 词：协同共刺激分子B7-H4 肝内胆管癌 病理 预后 

分 类 号：R735.7[医药卫生—肿瘤]